com)-- Tucson based pharmaceutical company NuvOx Pharma announced today that it has secured orphan drug designation from the FDA for its investigational radiosensitizer
for glioblastoma multiforme.
Curcumin: a new radiosensitizer
of squamous cell carcinoma cells.
Of special interests, curcumin acts as a chemosensitizer and radiosensitizer
for tumors while chemoprotector and radioprotector for normal organs (Goel and Aggarwal 2010).
Chemotherapy acts as a radiosensitizer
, and it helps decrease the rate of distant metastasis.
Related preclinical studies using Provecta(TM) as a radiosensitizer
currently are underway at the University of Wisconsin-Madison.
NCT01088035 ("Carboplatin as a Radiosensitizer
in Treating Childhood Ependymoma")
Research has also shown that VAL-083 is highly effective against GBM cancer stem cells (CSC) and non-CSC and acts as a radiosensitizer
in GBM cell lines, in vitro.
It is stated that Nimoral is a hypoxic radiosensitizer
to enhance the effect of radiotherapy in head and neck cancer patients.
Effect of a hypoxic radiosensitizer
, AK 2123 (Sanazole), on yeast Saccharomyces cerevisiae.
Background & objectives: Temozolomide (TMZ), a second generation alkylating drug, an effective cytotoxic agent as well as radiosensitizer
for malignant brain tumours, has side effects like myelosuppression.
Clinical trial as radiosensitizer
to start later in 2011-
iii) act as a radiosensitizer
and to synergistically enhance radiation-induced apoptosis.