radioligand


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radioligand

 [ra″de-o-li´gand]
a radioisotope-labeled substance, e.g., an antigen, used in the quantitative measurement of an unlabeled substance by its binding reaction to a specific antibody or other receptor site.

ra·di·o·li·gand

(rā'dē-ō-li'gand, rad'ē-ō-lig'and),
A molecule with a radionuclide tracer attached; usually used for radioimmunoassay procedures.
[radio- + L. ligandus, that which is to be bound, fr. ligo, to bind]

radioligand

/ra·dio·li·gand/ (-li´gand) a radioisotope-labeled substance, e.g., an antigen, used in the quantitative measurement of an unlabeled substance by its binding reaction to a specific antibody or other receptor site.

ra·di·o·li·gand

(rā'dē-ō-lī'gand)
A molecule with a radionuclide tracer attached; commonly used for radioimmunoassay procedures.
[radio- + L. ligandus, that which is to be bound, fr. ligo, to bind]

radioligand

a radioisotope-labeled substance, e.g. an antigen, used in the quantitative measurement of an unlabelled substance by its binding reaction to a specific antibody or other receptor site.
References in periodicals archive ?
18]F)-NOTA-labeled tetrazine radioligand for PET imaging and in vivo coupling, examining the efficiency of HuMab5B1 in imaging and the reduction in exposure to the radiolabel.
Specific binding was calculated by subtracting non-specific binding (defined as that seen in the presence of 1 [micro]M unlabeled GABA)--from the total binding obtained with radioligand alone.
In a group of cognitively normal elderly subjects, PET imaging with an investigational tau-specific radioligand showed a significant association between increased tau binding and progressive memory decline over 3 years.
Bioavailable 25(OH)D calculated using the VDBP concentration (R&D kit) and previously published affinity constants for Gc1F and Gc1S did correlate with values obtained with a radioligand binding assay.
125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man.
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay.
They were injected with a radioligand, 18F-FMPEP-d2, which is a combination of a radioactive fluorine isotope and a neurotransmitter analog that binds with CB1 brain receptors.
The influence of aging and of L-alpha-glycerylphos-phorylcholine (GFC) treatment on the acetylcholine synthesizing and degradating enzymes choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) and on cholinergic muscarinic M-1 and M-2 receptors were assessed in the hippocampus using immunocytochemical, histochemical and radioligand binding techniques, respectively.
50] value of binding, the concentration of the extract required to reduce the specific radioligand binding by 50 per cent was 185.
3]H]naltrindole was used as a radioligand for 5 opioid receptor while for competitive ligands were used mitragynine, naltriben, U-69593 and 7-benzillidinnaltrexone (BNTX).