In addition to Lutathera in NET, AAA's radioligand
therapy (RLT) pipeline includes 177Lu-PSMA-R2 which is currently being investigated in a phase 1/2 study in prostate cancer and other assets in pre-clinical testing, as well as a range of diagnostic programs.
Early clinical PET imaging results with the novel PHF-tau radioligand
AAA is a radiopharmaceutical company that works in the development, manufacturing and commercialisation of Molecular Nuclear Medicines, such as Lutathera (177Lu-DOTATATE), a first-in-class RadioLigand
Therapy (RLT) product for neuroendocrine tumors (NETs).
This technique yields reproducible results if the reporter ligand A forms a slowly dissociating complex (RA) that can be reliably separated from the excess of radioligand
Gabapentin is structurally related to the neurotransmitter GABA (Gamma aminobutyric acid), but it does not modify GABAA or GABAB radioligand
binding, it is not converted metabolically into GABA or a GABA agonist, and it is not an inhibitor of GABA uptake or degradation.
P Leamon, "Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand
binding assay," Anal.
Then they used PET to characterize uptake of 18F-AV-1451, a radioligand
for tau, in 53 adults.
cauliflora at 10 g/well showed no ability to inhibit specific radioligand
binding to 5HT1a, GABAB and dopamine (D2S) central nervous system receptors (Chung et al.
Looking in turn at ligand-gated ion channels, G protein-coupled receptors, and radioligand
binding, he consider such topics as the affinity and efficacy of orthosteric ligands at ligand-gated ion channels, the analysis of allosteric interactions at ligand-gated ion channels, the affinity and efficacy of the agonist-receptor-G-protein interaction, analyzing agonism and inverse agonism in signaling pathways that exhibit constitutive activity, and analyzing drug-receptor interaction using radioligand
binding assays on G protein-coupled receptors.
Specific binding was calculated by subtracting non-specific binding (defined as that seen in the presence of 1 [micro]M unlabeled GABA)--from the total binding obtained with radioligand
125]I]CLINME also showed significantly increased radioligand
binding in the lesioned striatum compared to the contralateral one (Figure 6).
68]Ga-labeled 1, 4, 7-triazacyclononane-1, 4, 7-triacetic acid-ubiquicidin as a radioligand
for PET infection imaging," Journal of Nuclear Medicine, vol.