radioligand


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radioligand

 [ra″de-o-li´gand]
a radioisotope-labeled substance, e.g., an antigen, used in the quantitative measurement of an unlabeled substance by its binding reaction to a specific antibody or other receptor site.

ra·di·o·li·gand

(rā'dē-ō-li'gand, rad'ē-ō-lig'and),
A molecule with a radionuclide tracer attached; usually used for radioimmunoassay procedures.
[radio- + L. ligandus, that which is to be bound, fr. ligo, to bind]

radioligand

/ra·dio·li·gand/ (-li´gand) a radioisotope-labeled substance, e.g., an antigen, used in the quantitative measurement of an unlabeled substance by its binding reaction to a specific antibody or other receptor site.

ra·di·o·li·gand

(rā'dē-ō-lī'gand)
A molecule with a radionuclide tracer attached; commonly used for radioimmunoassay procedures.
[radio- + L. ligandus, that which is to be bound, fr. ligo, to bind]

radioligand

a radioisotope-labeled substance, e.g. an antigen, used in the quantitative measurement of an unlabelled substance by its binding reaction to a specific antibody or other receptor site.
References in periodicals archive ?
In addition to Lutathera in NET, AAA's radioligand therapy (RLT) pipeline includes 177Lu-PSMA-R2 which is currently being investigated in a phase 1/2 study in prostate cancer and other assets in pre-clinical testing, as well as a range of diagnostic programs.
Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.
AAA is a radiopharmaceutical company that works in the development, manufacturing and commercialisation of Molecular Nuclear Medicines, such as Lutathera (177Lu-DOTATATE), a first-in-class RadioLigand Therapy (RLT) product for neuroendocrine tumors (NETs).
This technique yields reproducible results if the reporter ligand A forms a slowly dissociating complex (RA) that can be reliably separated from the excess of radioligand (Scheme 1).
Gabapentin is structurally related to the neurotransmitter GABA (Gamma aminobutyric acid), but it does not modify GABAA or GABAB radioligand binding, it is not converted metabolically into GABA or a GABA agonist, and it is not an inhibitor of GABA uptake or degradation.
P Leamon, "Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay," Anal.
Then they used PET to characterize uptake of 18F-AV-1451, a radioligand for tau, in 53 adults.
cauliflora at 10 g/well showed no ability to inhibit specific radioligand binding to 5HT1a, GABAB and dopamine (D2S) central nervous system receptors (Chung et al.
Looking in turn at ligand-gated ion channels, G protein-coupled receptors, and radioligand binding, he consider such topics as the affinity and efficacy of orthosteric ligands at ligand-gated ion channels, the analysis of allosteric interactions at ligand-gated ion channels, the affinity and efficacy of the agonist-receptor-G-protein interaction, analyzing agonism and inverse agonism in signaling pathways that exhibit constitutive activity, and analyzing drug-receptor interaction using radioligand binding assays on G protein-coupled receptors.
Specific binding was calculated by subtracting non-specific binding (defined as that seen in the presence of 1 [micro]M unlabeled GABA)--from the total binding obtained with radioligand alone.
125]I]CLINME also showed significantly increased radioligand binding in the lesioned striatum compared to the contralateral one (Figure 6).
68]Ga-labeled 1, 4, 7-triazacyclononane-1, 4, 7-triacetic acid-ubiquicidin as a radioligand for PET infection imaging," Journal of Nuclear Medicine, vol.