Rituximab is given to enable clearance of peripheral B-cells and to maximize biodistribution prior to radioimmunoconjugate
Iomab(TM)-B is a radioimmunoconjugate
consisting of BC8, a novel murine monoclonal antibody, and iodine 131 radioisotope.
In this new project, bavituximab will be labeled with radioactive isotopes to assess its potential as an imaging agent to identify tumor metastases and as a radioimmunoconjugate
to treat metastatic disease.
Zevalin is the first commercially available radioimmunoconjugate
Oncolym is the trade name for the radioimmunoconjugate
formed when the Lym-1 monoclonal antibody is attached to iodine-131, a radioactive form of iodine.
Early in the year, we extended our collaboration with Genentech to the development of IDEC-Y2B8, our radioimmunoconjugate
, for lymphoma.
for rights to IDEC-Y2B8, a radioimmunoconjugate
for treatment of non-Hodgkin's B-cell lymphomas, and a $1.
Their expertise in protein engineering, ADC technology and radioimmunoconjugates
complements the molecular imaging and mAb platform technology leadership present in our SAB.
Future immunotherapy-based treatments will be enhanced by the radioimmunoconjugates
and vaccine therapy.
For more than a decade, we have augmented these services by leveraging the bioconjugation experience and expertise of our staff to develop Antibody Drug Conjugates (ADCs), radioimmunoconjugates
and other bioconjugates.
Example of some topics covered in this publication include: -- Pancreatic Cancer -- Angiogenesis Inhibitors/Antimetastatic Agents And Targeted Delivery/Gene Transfer Approaches -- Endothelial Monocyte-activating Protein II (IMAP-II) -- Vascular Endothelial Growth Factor (VEGF) Inhibitors -- Urokinase Plasminogen Activator (uPA) System Inhibitors -- Other Antiangiogenesis Agents -- Targeted Drug Delivery -- Targeted Toxins -- Radioimmunoconjugates
-- Targeted Cytotoxics -- Gene Transfer -- Oncolytic Viruses
A number of other products, including THERATOPE (R) therapeutic injections, and Tru-Scint (R) diagnostic radioimmunoconjugates
, are at various phases in the clinical trial process.