radiation sensitizer

radiation sensitizer

Oncology Any agent which ↑ cell susceptibility to ionizing radiation Explanation Most CA cells are hypoxic and thus more resistant to radiation; a hypoxic-cell RS–eg, etanidazole, misonidazole, nimorazole would, theoretically, improve radiation killing of CA cells–results have been disappointing. See Radiation therapy.
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Zelefsky said the research team conducted the retrospective study because published studies had suggested statins also may have an apoptotic effect, may act as a radiation sensitizer, and may reduce cancer risk.
Allos has two product candidates in late-stage clinical development: EFAPROXYN (efaproxiral), a radiation sensitizer currently under evaluation in a pivotal Phase 3 trial in women with brain metastases originating from breast cancer, and PDX (pralatrexate), a novel, next-generation antifolate currently under evaluation in a pivotal Phase 2 trial in patients with relapsed or refractory peripheral T-cell lymphoma.
Preclinical data suggest that XYOTAX is a more effective radiation sensitizer than paclitaxel.
Allos Therapeutics expects to use the proceeds from the financing for the development of the company's lead investigational radiation sensitizer, RSR13 (efaproxiral), and for general working capital.
The researchers reported that a significant number of randomized studies have demonstrated that the addition of hyperthermia to radiation can improve response rate, local control and overall survival without a significant increase in toxicity, which makes hyperthermia a very attractive radiation sensitizer for radiation oncologists.
What some of the other trials underestimated is the capability of gemcitabine to serve as a radiation sensitizer, Dr.
Nasdaq: ALTH) announced today the presentation of updated results from its Phase 3 clinical trial of the investigational radiation sensitizer EFAPROXYN(TM) (efaproxiral) in patients with brain metastases.
In this trial, patients with advanced pancreatic cancer with no prior chemotherapy except as a radiation sensitizer received escalating doses of nab-paclitaxel (ABRAXANE([R])) from 100 mg/m2 to 150 mg/m2 combined with 1000 mg/m2 of gemcitabine.
The study is the first to demonstrate the utility of GRN163L as a radiation sensitizer in cancer therapy.
Phase II clinical data on OPAXIO demonstrated high rates of pathologic complete remissions for treatment of patients with advanced esophageal cancer paving way for potential registration trial as radiation sensitizer.
Randomized Trial Shows that IOERT, When Used in Combination with a Radiation Sensitizer, Achieved a Three-Year Survival of 23% Versus 0% for Those Not Receiving the Sensitizer
Intae Lee with the University of Pennsylvania has reported that Alfacell's ONCONASE (ranpirnase) could be a promising radiation sensitizer for lung cancer treatment.

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