is a substance containing equal amounts of two
Although none of the previously separated enantiomers had exhibited any improved properties over their racemates, the Sanofi scientists again attempted to separate the enantiomers of another promising compound, designated PCR 4099.
has obtained patents on single-enantiomer versions of sixteen chiral drugs previously sold as racemates by other companies.
Chemical synthesis almost invariably lacks the stereo-discriminating power of enzymatic or biofermentation methods and thus can yield a racemate or disproportionate mix of isomers.
As described previously, supplementation with a racemate of carnitine can have adverse effects, which may mimic actual deficiency of carnitine, perhaps via the enantiomers competing for transport into cells (Watanabe S.
Because of the expensive rare metals used to construct chiral catalysts, single enantiomers usually cost more than racemates to produce.
Some researchers liken the use of drug racemates to dumping toxic waste in the body.
MDMA is a chiral compound used as a racemate
, and an examination of the pharmacological activity of the individual enantiomers indicates that the (+)-S-enantiomer is more active in terms of "the degree and the disruptiveness of the induced intoxication" (12) than the (-)-R-enantiomer.
Create optically pure forms of branded racemates
Tramadol and its major metabolite, M1, are racemates
Cortech's Chairman and CEO, Paul Koether, stated: "We are pleased with the findings of the arbitration panel in that Ono's rights to compounds derived from Cortech's intellectual property and library of compounds are limited to, at most, 17 specifically identified compounds and their isomers and racemates
The Early History of Stereochemistry: From the Discovery of Molecular Asymmetry and the First Resolution of a Racemate
by Pasteur to the Asymmetrical Chiral Carbon of Van't Hoff and Le Bel.