137) However, even if there exists an expectation of improved properties for a single enantiomer, the enantiomer may not be obvious over its racemate
if there is no disclosed means of resolution.
It requires converting the enantiomers in a racemate
to a pair of diastereomers, or isomers that have different solubilities.
Twice a winner of big handicaps this autumn, Racemate
will step up to Group level next year.
, including the racemate
from which the separated isomers were
D]/F = CL/k) were calculated by considering the dose (D) to be equal to one-half the administered dose of the racemate
, and F to be the systemic availability.
In contrast to the synthetic racemate
, the natural product exclusively contains the D-isomer (Belz et al.
POTENTIAL CLINICAL APPLICATIONS OF CHIRAL PHARMACOLOGY AND RACEMATE
Notably the synthesis of MK-0679 (the R-enantiomer) was significantly more efficient than the synthesis of the racemate
in the early 1980s it was offered only as the racemate
(a "racemic" dl-carnitine mixture, defined by the presence of near equal amounts of both the d- isomer and the l- isomer.
In this work, we evaluated individually the anti-inflammatory properties of (-) linalool, that is, the natural occurring enantiomer, and its racemate
form, present in various amounts in distilled or extracted essential oils.
In addition, the R-isomer of flurbiprofen has been shown in animal models to be a potent antiproliferative for normal colonocytes, colon polyps, and adenocarcinomas without the gastrointestinal toxicity of the S-isomer or the racemate
One active component of DULERA is formoterol fumarate dihydrate, a racemate