virus from Utrecht has a unique deletion of only 2 residues (254, 255); VACV-3737 and VACV-Malbran share a 5--amino acid deletion (245-249).
10) Their results have since been replicated, and methods have been improved to produce even deadlier strains of mousepox and rabbitpox
The study demonstrated that both products, alone and in combination, were able to protect 100% of rabbits from rabbitpox virus (RPV) infection, suggesting that these products possess potent anti-viral properties and are ideal candidates to evaluate as preventatives for human smallpox.
Government, and in this early study, we targeted rabbitpox because it serves as an excellent preliminary model for the development of therapies for human smallpox.
The VACV variants buffalopox and rabbitpox
have originated from VACV subspeciation (13).
The Attenuated Vaccinia-Lister Vaccine LC16m8 Protects Rabbits from Lethal Rabbitpox
Secondly, the rabbitpox model is important in that it allows us to test for the impact of modifying a gene called B5R, which is heavily involved in the disease process in rabbits, on the efficacy of LC16m8.
LC16m8 Protects Rabbits Against Lethal Rabbitpox Challenge
A separate study titled "The Attenuated Vaccinia-Lister Vaccine LC16m8 Protects Rabbits from Lethal Rabbitpox Challenge" was funded by VaxGen and conducted by scientists at VaxGen, University of Florida, University of Pennsylvania and Vanderbilt University.