r-tPA

r-tPA

recombinant tissue Plasminogen activator
References in periodicals archive ?
They are also actively recruiting patients in our Phase 2 combination study with MST-188 and r-tPA in acute limb ischemia, and have us poised to launch a third clinical study in heart failure next year.
Now, researchers are studying several therapies that, when combined with r-tPA, may not only clear the clot but also prevent a recurrence.
Researchers at the University of Michigan in Ann Arbor have compared the use of r-tPA alone with the use of r-tPA combined with coronary angioplasty.
In patients receiving r-tPA alone, the affected arteries were up to 75 to 80 percent narrower than normal after treatment.
Even after the combination of angioplasty and r-tPA, two of the eight patients in that treatment group had a recurrence of the clot.
The IMS III Trial was a prospective, randomized trial comparing two different treatment approaches--combined intravenous (IV) and intra-arterial (IA) therapy, and standard IV r-tPA (clot-busting drug)--to restoring blood flow to the brain.
Patients will be assigned to either IV r-tPA therapy alone or a combined IV r-tPA therapy and intra-arterial (IA) treatment with the Penumbra System.
The study, presented today at the annual meeting of the American College of Cardiology, showed that patients who received the investigational drug, RheothRx, plus either streptokinase or r-tpa, had an infarct size 38 percent smaller than patients who received either of the thrombolytics with a placebo.
The study enrolled 114 patients who were randomized to receive either streptokinase or r-tpa, plus RheothRx (75 patients), or one of the two thrombolytics plus placebo (39 patients).
The trial is examining if a combined approach of intravenous r-tPA and intra-arterial intervention is more likely to produce a better outcome for patients than intravenous r-tPA alone, and it's important that the trial reflect current standards of care among our investigators.
The purpose of this study is to compare two different treatment approaches -- combined intravenous and intra-arterial (IA) therapy and standard intravenous (IV) r-tPA -- to restoring blood flow to the brain.