control wells (eight replicates) contained cell-free culture supernatant (100 [micro]l) obtained from P.
The findings indicate that Ruegeria KLH11 uses quorum sensing
in a previously unsuspected way, to activate "a dispersal mechanism that promotes the uniform distribution of these bacteria in the local environment when the population becomes too dense," says coauthor Clay Fuqua, a professor of biology at Indiana University Bloomington.
According to the scientists, micro-organisms inhabiting these mats produced quorum sensing
inhibitors under natural conditions.
Recent quorum sensing
investigations have demonstrated that some bacteria, plants and animals are capable of producing compounds that can disrupt the bacteria's ability to communicate and thereby disable bacterial growth and the ability to become pathogenic.
In some bacteria, quorum sensing
triggers the production of enzymes that catalyze light-producing reactions.
Of significance is the role that quorum sensing
plays in pathogenesis.
How bacteria talk to each other: Regulation of gene expression by quorum sensing
SAN DIEGO -- Pico Pharmaceuticals today announced a publication in the journal Nature Chemical Biology that supports a novel mechanism for the inhibition of quorum sensing
pathways in bacterial pathogenesis.
Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing
Sorrento's anti-MRSA program specifically targets auto-inducing peptides (AIPs) central to the quorum sensing
system of S.
From a technical perspective, the ajoene blocks the communication system - known as Quorum Sensing
- in the bacteria, which is used for purposes including creating infection.
The approach in BYEFOULING is to tackle the different stages of the biofouling process using innovative antifouling agents, covering surface-structured materials, protein adsorption inhibitors, quorum sensing
inhibitors, natural biocides and microorganisms with antifouling properties.