quorum sensing


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quorum sensing

a phenomenon in bacteria that limits certain behaviors to occurring only above a certain population density.

quorum sensing

n.
A phenomenon in which a population of bacteria produces and responds to intercellular chemical signals whose concentration indicates the density of the population. When the density reaches a certain level, genes are expressed that allow for coordinated group behavior, as in bioluminescence or the formation of biofilms.

quo·rum sens·ing

(kwōr'ŭm sens'ing)
A process whereby bacteria communicate by means of extracellular molecules called pheromones.

quorum sensing

a process in which unicellular organisms secrete signal molecules that influence the behaviour of a population of identical organisms, but only when the density (number of cells per unit volume) of that population is above a certain level. Cells sense the concentration of the secreted signal molecule, often a homoserine lactone, which tells them how many other cells are in their environment. When a threshold concentration of the signal molecule is reached, the population density has achieved a critical level or quorum, and quorum-dependent genes are expressed by auto induction. A given species can produce a range of autoinducer signal molecules, which regulate expression of genes governing characteristics that are only exhibited above this critical population density Thus specific characteristics may be displayed by cells present at high density, but not by the same cells when present at low density Examples of quorum sensing include, bioluminescence of Photobacterium fischeri when occurring as a SYMBIONT in high density populations, but not when free-living in low density populations; promotion of COMPETENCE for TRANSFORMATION in Bacillus subtilis, when present at high density; and production of VIRULENCE factors in Pseudomonas aeruginosa.
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The authors' work supports the role of MTAN in quorum sensing and demonstrates the potential to regulate virulence through MTAN inhibition.
Our study is part of a series of comprehensive investigations of natural compounds targeting bacterial quorum sensing systems, and it further strengthens previous proof of concept research we conducted on the potential of compounds which block communication among pathogen cells in contrast to simply killing bacteria, as conventional antibiotics do," says Jakobsen.
En nuestros dias el termino de quorum sensing se usa para describir el fenomeno en el cual la acumulacion de moleculas senales permite a una celula individual percibir el numero de bacterias (densidad celular) que tiene a su alrededor por la deteccion y reaccion con estos compuestos, esto es suficiente para que las bacterias inicien la expresion coordinada de genes especificos, lo que implica un cambio en su comportamiento hacia una fase multicelular.
Secretions from normal bacteria reduced the ability of skin cells to fill the gap (a key process in wound healing called migration) substantially more than secretions from the strain with disabled quorum sensing genes.
The bacteria on the pellicle undergo cell to cell interaction via quorum sensing.
Two different biosensors were used to evaluate the quorum sensing inhibition properties of compounds and extracts.
Halting a quorum sensing factor could one day translate to a treatment for bacterial infections.
The colonies are synchronized via the gas signal, but the cells are synchronized via quorum sensing.
Henry Ji, chief scientific officer of Sorrento Therapeutics, said that this discovery programme represents a novel approach to fighting MRSA, and Sorento also sees interference with quorum sensing as a more general approach to address the serious issue of antibiotic resistance beyond MRSA.
Spectrum expert commentary: an award-winning researcher explains how quorum sensing may shine light on a new path to novel antibacterial drug development.
Quorum sensing (QS) is a process of cell-cell communication mechanism occurs between the bacterial cells through the secretary signal molecules.