NADPH dehydrogenase (quinone)

(redirected from quinone reductase)

NADPH de·hy·dro·gen·ase (quin·one)

a flavoprotein that oxidizes NADH or NADPH to NAD+ or NADP+ with quinones (for example, menadione) as hydrogen acceptors.
References in periodicals archive ?
Quinone reductase enzymatic activity, a surrogate of global phase 2 enzyme activity, was assayed by the menadione-coupled reduction of tetrazolium dye.
We measured the quinone reductase (QR) activity using a spectrophotometric assay in which we monitored the rate of reduction of 2,6-dichlorophenolindophenol at 590 nm with the spectrophotometer (Rengasamy et al.
Inhibition of nitric oxide formation by neuronal nitric oxide synthase by quinones: nitric oxide synthase as a quinone reductase.
Called quinone reductase, this detoxifying enzyme heads off the production of hydroxyl radicals, a type of chemically reactive molecular fragment.
When we measured MIBITC activity on the phase II detoxification enzyme quinone reductase in the HepG2 human liver cell line, we saw activity similar to the concentrations of pure sulforaphane," said Dr.
glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and glucuronosyltransferases] is a powerful strategy for achieving protection against carcinogenesis, mutagenesis, and other forms of toxicity of electrophiles and reactive forms of oxygen.
Induction of NAD(P)H: quinone reductase in murine hepatoma cells by phenolic antioxidants azo dyes and other chemoprotectors: a model for the study of anticarcinogens.
Additionally, glutathione-S-transferase and quinone reductase activities in the mouse uterus were significantly lowered in a dose-dependent manner following 17[beta]-estradiol exposure.
Dietary quercetin glycosides: antioxidant activity and induction of the anticarcinogenic phase II marker enzyme quinone reductase in Hepa1c1c7 cells.
Students that took part in the course practiced culturing a human liver cancer cell line and took the opportunity to measure the response of these cells to the extracts from various vegetables in terms of the activity of quinone reductase, an enzyme that plays a role in cellular detoxification.
5) In experimental studies of cancer formation, quinone reductase has been shown to dose-dependently inhibit the growth of cancer cells.