quinolones


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Related to quinolones: ciprofloxacin, Aminoglycosides

quin·o·lones

(kwin'ō-lōnz),
A class of synthetic broad-spectrum antibacterial agents with bactericidal action (for example, ciprofloxacin).

quin·o·lones

(kwin'ō-lōnz)
A group of antimicrobial agents (e.g., norfloxacin, ciprofloxacin, levofloxacin) that block bacterial DNA synthesis.

quinolones

A group of synthetic antibiotic drugs that includes nalidixic acid, oxfloxacin and enoxacin. These drugs act by inactivating an enzyme, DNA gyrase, necessary for replication of the organisms.

quinolones 

A class of broad-spectrum antibacterial drugs of which the main ophthalmic agents are ciprofloxacin and ofloxacin. They are used topically in 0.3% solution. They are effective against the majority of gram-negative pathogens, including Haemophilus, Neisseria gonorrhoeae, Chlamydia trachomatis, Pseudomonas aeruginosa (especially ciprofloxacin), staphylococci and streptococci. They are used in the treatment of conjunctivitis, blepharitis, keratoconjunctivitis and corneal ulcers. See antibiotic.

quin·o·lones

(kwin'ō-lōnz)
Synthetic broad-spectrum antibacterial agents with bactericidal action.

quinolones

drugs that have good effect against all species of chicken coccidia but have a bad tendency to generate resistant strains and are now rarely used for that purpose; newer derivatives are used as antibacterials.
References in periodicals archive ?
The researchers narrowed the most effective drug candidates in the quinolones series to one lead drug - ELQ-300 - now moving toward clinical testing.
But prescriptions for quinolones grew by 10%, and prescriptions for cephalosporins grew by 3%, which were statistically significant increases (P less than .
Quinolones act by inhibiting bacterial DNA gyrase and/or topoisomerase IV (2).
OBJECTIVES: We investigated the distribution of plasmid-mediated quinolone resistance (PMQR) genes from swine feedlots and their surrounding environment.
It suggests that mutations in gyrA might determine the main resistance ability to quinolone, while additional parC mutation might mediate a higher level of resistance to quinolones.
The study's authors said a few individuals traveling outside the region may have been exposed to quinolones and on return transmitted resistant organisms to their neighbors.
Two other quinolones, norfloxacin and lomefloxacin, are used primarily to treat urinary tract and prostate infections, and ofloxacin is another that is manufactured in a topical form for ear and eye disease.
Quinolones, in Mandell GL, Bemlett JE, Dolin R (eds): Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases.
One would hope that their further characterization and source search would include ongoing investigation of resistance to quinolones.
Since 1995, when the Food and Drug Administration approved quinolones for use in poultry, the rates of resistance have gone up dramatically.
Exemplary compositions in this class include: pentoxifylline; isobutylmethyl xanthine; ciprofloxacin; rolipram; terferol; and the quinolones generally.
Specifically, the study identified through computational analysis a set of molecular features unique to delafloxacin that deliver enhanced potency as compared to other quinolones.