quinolone

quinolone /quin·o·lone/ (kwin´o-lōn) any of a group of synthetic antibacterial agents that includes nalidixic acid and the fluoroquinolones.

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quin·o·lone (kwn-ln)

n.

Any of a class of synthetic broad-spectrum antibacterial drugs derived from quinoline compounds.

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quinolone

[kwin′əlōn]

any of a class of antibiotics that act by interrupting the replication of deoxyribonucleic acid (DNA) molecules in bacteria. The action involves inhibition of the bacteria's gyrase so that positively supercoiled DNA cannot be relaxed for DNA transcription and replication. An example is ciprofloxacin.

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quinolone (kwin´lōn´),

n a class of antibiotics that act by interrupting the replication of deoxyribonucleic acid molecules in bacteria.

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quinolone

Fluoroquinolone Infectious disease Any of a family of broad-spectrum oral antibiotics–eg, ciprofloxacin, norfloxacin, and ofloxicin, which target bacterial DNA gyrase and concentration-dependent inhibitors of DNA synthesis; bacterial resistance to quinolones is rare and hinges on mutations of gyrase; quinolones are active against most aerobes, including bacteria resistant to other antibiotics; they are effective in GI, GU, prostatic, respiratory infections, STDs Adverse effects GI discomfort, vague CNS Sx