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quinolone/quin·o·lone/ (kwin´o-lōn) any of a group of synthetic antibacterial agents that includes nalidixic acid and the fluoroquinolones.
Any of a class of synthetic broad-spectrum antibacterial drugs derived from quinoline compounds.
any of a class of antibiotics that act by interrupting the replication of deoxyribonucleic acid (DNA) molecules in bacteria. The action involves inhibition of the bacteria's gyrase so that positively supercoiled DNA cannot be relaxed for DNA transcription and replication. An example is ciprofloxacin.
anabolic steroidA drug or hormone-like substance chemically or pharmacologically related to 17-α-alkylated testosterone that promotes muscle growth, which are commonly abused by athletes. Lipid changes by ASs are more marked with oral stanazol (manufactured for horses) than with IV testosterone; it decreases HDL-C (especially HDL2) and increases hepatic TG lipase (HDL) catabolism.
Children, adolescents with delayed puberty, decreased growth, small penis, hypogonadism, testosterone deficiency, osteoporosis management, aplastic anaemia, endometriosis, angioedema, sports performance enhancement (no longer legal), relief and recovery from common injuries, rehabilitation, weight control, anti-insomnia, and regulation of sexuality, aggression and cognition.
Increased protein synthesis and amino acid consumption, androgenesis, catabolism and gluticocototitosis.
Adverse effects (men)
Breast enlargement (gynecomastia), testicular atrophy, sterility, sperm abnormalities, impotence, prostatic hypertrophy, myocardial hypertrophy and fibrosis, myocardial infarction and fatal arrhythmias, peliosis hepatis, cholestasis, hepatic adenomas, testicular atrophy, peripheral oedema, intracerebral thrombosis.
Adverse effects (women)
Clitoral hypertrophy, beard growth, baldness, deepened voice, decreased breast size.
Adverse effects (men and women)
Aggression and antisocial behavior, increased risk of cardiovascular disease, peliosis hepatis, haemorrhage, jaundice, acne, accelerated bone maturation resulting in short stature, liver tumours (hepatic adenomas and CA) which may regress with abstinence; AS abusers are at an increased risk for HIV transmission, given the common practice of sharing of needles when injecting ASs.
ASs are detectable to 1 parts per billion 4 days after last use if the hormone is water-soluble, or 14 days after use in lipid-soluble compounds.
ASs are schedule-III drugs per the Controlled Substances Act.
quinoloneFluoroquinolone Infectious disease Any of a family of broad-spectrum oral antibiotics–eg, ciprofloxacin, norfloxacin, and ofloxicin, which target bacterial DNA gyrase and concentration-dependent inhibitors of DNA synthesis; bacterial resistance to quinolones is rare and hinges on mutations of gyrase; quinolones are active against most aerobes, including bacteria resistant to other antibiotics; they are effective in GI, GU, prostatic, respiratory infections, STDs Adverse effects GI discomfort, vague CNS Sx
n a class of antibiotics that act by interrupting the replication of deoxyribonucleic acid molecules in bacteria.