The results also showed decreased quinolinic acid
levels among a subset of patients who came back six months later, when their suicidal behavior had ended.
These findings support earlier theories that inflammation in the brain is a risk factor in suicide, as the body produces quinolinic acid
as part of the immune system respond and creates inflammation.
What is the output and capacity of quinolinic acid
from producers in China in 2011?
Metabolism and neuropathologic significance of quinolinic acid
and kynurenic acid.
is associated with inflammation such as arthritis and is considered to be neurotoxic, with a probable role in Parkinson's syndrome, Alzheimer's disease, Huntington's disease, and schizophrenia.
In human macrophages, conversion of Trp into quinolinic acid
increases under interferon-[gamma] stimulation (6).
The model used was based on the injection of quinolinic acid
(QA) into the striatal region of the primates' brains to produce death of the specific neurons similar to those lost in Huntington's disease.
The two main chemicals believed responsible for the nerve cell degeneration -- quinolinic acid
and glutamate -- occur naturally and play essential roles at their normal concentrations in the body.
for his project entitled "Effects of Quinolinic Acid
on Cognitive Processing.
The rationale behind the therapy comes from evidence that the neurological problems associated with Huntington's may be due in part to brain damage caused by a brain chemical, quinolinic acid
The most commonly studied animal model of Huntington's disease involves the injection of a chemical, quinolinic acid
, into the brains of animals, thereby causing a pattern of cellular damage which remarkably resembles that seen in people with Huntington's disease.
Martin's group recently reported that they were able to produce the Huntington's pattern of neuronal destruction by injecting the excitotoxin quinolinic acid
into rat brains.