quinolinic acid

Also found in: Acronyms.

quin·o·lin·ic ac·id

(kwin'ō-lin'ik as'id),
A catabolite of l-tryptophan and a precursor of NAD+.
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The results also showed decreased quinolinic acid levels among a subset of patients who came back six months later, when their suicidal behavior had ended.
These findings support earlier theories that inflammation in the brain is a risk factor in suicide, as the body produces quinolinic acid as part of the immune system respond and creates inflammation.
What is the output and capacity of quinolinic acid from producers in China in 2011?
Metabolism and neuropathologic significance of quinolinic acid and kynurenic acid.
Quinolinic acid is associated with inflammation such as arthritis and is considered to be neurotoxic, with a probable role in Parkinson's syndrome, Alzheimer's disease, Huntington's disease, and schizophrenia.
In human macrophages, conversion of Trp into quinolinic acid increases under interferon-[gamma] stimulation (6).
The model used was based on the injection of quinolinic acid (QA) into the striatal region of the primates' brains to produce death of the specific neurons similar to those lost in Huntington's disease.
The two main chemicals believed responsible for the nerve cell degeneration -- quinolinic acid and glutamate -- occur naturally and play essential roles at their normal concentrations in the body.
The rationale behind the therapy comes from evidence that the neurological problems associated with Huntington's may be due in part to brain damage caused by a brain chemical, quinolinic acid.
The most commonly studied animal model of Huntington's disease involves the injection of a chemical, quinolinic acid, into the brains of animals, thereby causing a pattern of cellular damage which remarkably resembles that seen in people with Huntington's disease.
Martin's group recently reported that they were able to produce the Huntington's pattern of neuronal destruction by injecting the excitotoxin quinolinic acid into rat brains.