quinidine


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Related to quinidine: quinine, Quinidine sulfate

quinidine

 [kwin´ĭ-dēn]
the dextrorotatory isomer of quinine, administered orally as the gluconate, polygalacturonate, or sulfate salts, or intravenously as the gluconate salt in treatment of cardiac arrhythmias. It is also administered intravenously as the gluconate salt in the treatment of life-threatening malaria caused by Plasmodium falciparum.

quin·i·dine

(kwin'i-dēn, -din),
One of the alkaloids of cinchona, a stereoisomer of quinine (the C-9 epimer); used as an antimalarial; also used in the treatment of atrial fibrillation and flutter, and paroxysmal ventricular tachycardia.
Synonym(s): conquinine

quinidine

/quin·i·dine/ (kwin´ĭ-dēn) the dextrorotatory isomer of quinine, used in the form of the gluconate, polygalacturonate, and sulfate salts in the treatment of cardiac arrhythmias; also used in the treatment of severe falciparum malaria.

quinidine

(kwĭn′ĭ-dēn′)
n.
A bitter alkaloid, C20H24N2O2, that is a stereoisomer of quinine, used in the form of its salts to treat malaria and certain cardiac arrhythmias.

quinidine

[kwin′ədēn, -din]
an antiarrhythmic agent administered as a bisulfate, gluconate, or polygalacturonate or as sulfate salts.
indications It is prescribed in the treatment of atrial flutter, atrial fibrillation, premature ventricular contractions, and tachycardias.
contraindications Known hypersensitivity to this drug prohibits its use. It is contraindicated in thrombocytopenia, myasthenia gravis, and some arrhythmias, particularly those associated with heart block.
adverse effects Among the most serious adverse effects are cardiac arrhythmia, hypertension, and cinchonism. Rare but potentially fatal hypersensitivity reactions such as anaphylaxis and thrombocytopenia may occur. Diarrhea, nausea, and vomiting are common.

quinidine

Duraquin®, Quinaglute® Cardiology A class Ia antiarhythmic that ↓ myocardial excitability, conduction velocity, and contractility. See Therapeutic drug monitoring.

quin·i·dine

(kwin'i-dēn)
A cinchona alkaloid; used as an antimalarial and to treat atrial fibrillation and flutter.
Synonym(s): conquinine.

quinidine

A drug derived from QUININE and used to control irregularity or excessive rapidity of the heart beat by depressing the excitability of the muscle. The drug is on the WHO official list. A brand name is Kinidin Durules.

quinidine

the dextrorotatory isomer of quinine, used in treatment of cardiac arrhythmias. Several salts are used, including the gluconate, sulfate and bisulfate.
References in periodicals archive ?
The 93 patients randomized to the investigational treatment started on 20 mg dextromethorphan and 10 mg quinidine administered orally once daily for a week, followed by an up-titration schedule over 2 weeks to reach 30 mg dextromethorphan twice daily plus 10 mg quinidine twice daily, the dosage they continued for an additional 7 weeks.
The most potent QT-prolonging medications are antiarrhythmic agents, particularly amiodarone, dofetilide, quinidine, and sotalol, with quinidine possibly having the most torsadogenic potential.
27) and, with the decreased use of quinidine as an antiarrhythmic agent, cases of poor outcomes including deaths have been reported due to a lack of available quinidine in hospital formularies.
The anti-arrhythmic effect of quinidine is better demonstrated on rabbit atria in which arrhythmia is induced electrically (Turner 1965).
Quinidine has been indicated to alter the pharmacokinetics of digoxin by all three of these mechanisms, whereas verapamil inhibits the biliary and renal elimination of digoxin.
PHILADELPHIA -- A combination drug of dextromethorphan and quinidine significantly reduced aggression and agitation in patients with Alzheimer's disease.
The acquisition integrates the buyer's psychiatric products, led by the anti-psychotic AbilifyA (aripiprazole), with Avanir's marketed Nuedexta, a mix of dextromethorphan and quinidine that is FDA's first approved treatment indicated for Pseudobulbar Affect (PBA), and several Avanir drug candidates.
He was administered quinidine, which is used to put the heart back into rhythm, and it went back almost immediately.
2mEq/L Nortriptyline Antidepressant/analgesic 50-150ng/mL (neuropathic pain) Phenobarbital Antiepileptic 15-40mcg/mL Phenytoin Antiepileptic 10-20mcg/mL Primidone Antiepileptic 5-12mcg/mL Procainamide Antiarrhythmic PA:4-8mcg/mL (NAPA: (PA) 10-20mcg/mL) (metabolite: NAPA) Protriptyline Antidepressant 70-250ng/mL Quinidine Antiarrhythmic 2-5mcg/mL Salicylate Analgesic/anti-inflammatory 10-30 mg/L Sirolimus Immunosuppressant 5-15ng/mL Tacrolimus Immunosuppressant 5-20 ng/mL Theophylline Bronchodilator 5-20mcg/mL Valproic acid Antiepileptic/mood 50-125mcg/mL stabilizer Vancomycin Antimicrobial Trough concentrations: General: 10-15mcg/mL Pneumonia: 15-20mcg/mL Voriconazole Antifungal >0.