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quasi-species

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quasi-species
a term used to describe a cluster (or cloud or swarm) of variant viruses that arise from mutations over time within a viral isolate, even a cloned isolate. Seen particularly with RNA viruses because of the inherently high mutation rate caused by copy errors during replication by RNA-dependent RNA polymerase and the absence of proof-reading in RNA replication.
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While in many circumstances it may be sufficient to use a tropism test with good rather than 'perfect' sensitivity to determine whether the dominant quasi-species is R5, it will always remain an important principle of antiretroviral therapy to ensure that the smCCR5 inhibitor is well supported by other active drugs in the regimen, and that prolonged virological failure is avoided.
Resistance testing methodologies and mechanisms of resistance by Geretti, Anna Maria / Journal of HIV Therapy
As a result, this method is likely to be of greater value for organisms with dsDNA genomes such as bacteria, eukaryotic parasites, and dsDNA viruses (in which quasi-species are less common because of more accurate replication) than for organisms with single negative-stranded RNA genomes (in which quasispecies are more common because their replication depends on the error-prone reverse transcriptase--HIV, hepatitis C, hepatitis B) (39,40).
Identifying and quantifying genotypes in polyclonal infections due to ... by Krogstad, Donald J. / Emerging Infectious Diseases
The accurate sequencing of viral genomes, including quasi-species and other heterogeneous data, requires the capability to detect multiple peaks in any location and distinguish true secondary peaks from noise.
Paracel Announces AGENT 2.0 at Bio-IT World Conference and Expo; ... by Business Wire
 
 
 
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