pyruvate dehydrogenase complex


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py·ru·vate de·hy·dro·gen·ase

a structurally distinct collection of enzymes containing pyruvate dehydrogenase (lipoamide), dihydrolipoyl transacetylase, and dihydrolipoyl dehydrogenase.

pyruvate dehydrogenase complex

[pī′ro̅o̅·vāt dē·hī′drō·jən·ās]
a multienzyme complex consisting of at least three distinct enzymes that catalyzes the formation of acetyl coenzyme A from pyruvate and coenzyme A. The acetyl coenzyme A is used in fatty acid synthesis, for acetylations, and for oxidation by means of the citric acid cycle. Deficiency of any component of the complex results in excess of lactic acid in the blood, ataxia, and psychomotor retardation.
References in periodicals archive ?
Spectrophotometric measurement of pyruvate dehydrogenase complex activity in cultured human fibroblasts.
Measurement of totally activated pyruvate dehydrogenase complex activity in human muscle: evaluation of a useful assay.
Enzyme inhibitory autoantibodies to pyruvate dehydrogenase complex in primary biliary cirrhosis: applications of a semi-automated assay.
This last group includes disorders of gluconeogenesis, the pyruvate dehydrogenase complex, the Krebs cycle, and the mitochondrial electron transport chain [1].