pyruvate dehydrogenase

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py·ru·vate de·hy·dro·gen·ase

a structurally distinct collection of enzymes containing pyruvate dehydrogenase (lipoamide), dihydrolipoyl transacetylase, and dihydrolipoyl dehydrogenase.

pyruvate dehydrogenase

(1) Puruvate dehydrogenase (cytochrome), EC (a deleted enzyme name, now covered by pyruvate dehydrogenase (quinone), EC
(2) Pyruvate dehydrogenase (acetyl-transferring), EC


a salt, ester or anion of pyruvic acid. The term is used interchangeably with pyruvic acid. Pyruvate is the end product of glycolysis and may be metabolized in the body to lactate or to acetyl CoA. In yeast it is metabolized to ethanol.

pyruvate carboxylase
an enzyme concerned in the conversion of pyruvate to oxaloacetic acid.
pyruvate dehydrogenase
actively concerned in the decarboxylation of pyruvate to acetyl CoA and CO2.
pyruvate kinase
a glycolytic pathway enzyme (called also PK) which catalyzes the formation of pyruvate from phosphoenolpyruvate (PEP). A deficiency of the enzyme is a hereditary defect in humans and occurs also in Beagle and Basenji dogs, causing a familial nonspherocytic anemia.
pyruvate transaminase
References in periodicals archive ?
The same messengers inside mitochondria might activate pyruvate dehydrogenase phosphatase (PDHP), thereby activating pyruvate dehydrogenase and oxidative glucose metabolism [51].
The complex also contains two specific phosphorylation-dephosphorylation enzymes, pyruvate dehydrogenase kinase (PDK) and pyruvate dehydrogenase phosphate phosphatases (PDP).
The nair, schizophrenic, autistic and civilisational disease group had features of Neanderthal metabolism as indicated by pyruvate dehydrogenase suppression.
Potential dysregulation of the pyruvate dehydrogenase complex by bacterial toxins and insulin.
In patients where pyruvate dehydrogenase deficiency is strongly suspected, these guidelines should be adapted.
6] demonstrated that pyruvate production increased in a sepsis-associated inflammatory state; second, muscle lactate production increases over time as the Na+K+ ATPase pump is activated in septic shock (8), and finally the pyruvate dehydrogenase complex is inhibited by endotoxin, thus inhibiting the movement of pyruvate into the Krebs cycle5.
Postischemic hyperoxia reduces hippocampal pyruvate dehydrogenase activity.
He describes the concepts behind gene genealogies, include genealogical thinking, mutation and mutation models, measures of DNA polymorphism and, by way of example, variation at the pyruvate dehydrogenase E1 alpha (or PDHA1) subunit.
It has been reported that insulin exerts a very strong effect on macrophage action by increasing pyruvate dehydrogenase (PDH) complex activity and some other enzymes that play an important role in their phagocyte capacity.
They created two new biosynthetic pathways--in effect transplanting four enzymes from bacteria and making new use of one of the plants' native enzymes, the pyruvate dehydrogenase complex, or PDC.
Hollie is 4 years old and has pyruvate dehydrogenase deficiency--a mitochondrial disease.