control group STZ: Streptozocin, PDTC: Pyrrolidine
To further investigate the mechanism of PC-induced NO and TNF-[alpha] production, we examined the ability of nuclear factor-[kappa]B (NF-[kappa]B) inhibitor such as pyrrolidine
dithiocarbamate (PDTC) (13) to block PC-induced effect.
dithiocarbamate inhibits the production of interleukin-6, interleukin-8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity.
NDC's proprietary pyrrolidine
alkaloid has been found to be a powerful recruiter and mobilizer of stem cells in the body.
To further investigate the role of NF-KB pathway in the regulation of CTGF expression during cardiac fibrosis, the cultured rat cardiac fibroblasts were treated with pyrrolidine
dithiocarbamate (PDTC), an inhibitor for NF-KB (Snyder et al.
The increased production of NO from rIFN-[gamma] plus KJE-stimulated cells was almost completely inhibited by pre-treatment with pyrrolidine
dithiocarbamate, an inhibitor of nuclear factor kappa B (NF-[kappa]B).
We modified the method slightly by replacing the original complexing agent, ammonium pyrrolidine
dithiocarbamate, with diethyldiammonium diethyldithiocarbamate, which gave a more stable lead complex.
This hypothesis is mainly based on the findings that strong anti-oxidants like N-acetyl-L-cysteine (NAC) and pyrrolidine
dithiocarbamate (PDTC) can inhibit NF-kappa B activation in a wide variety of cell types (Schreck et al.
Because oxidation of the pyrrolidine
ring leads to a reduction of nicotine's basic characteristics, cotinine should be largely unionized within the usual physiologic urinary pH range, which is consistent with the p[K.
Based on this and numerous reports, a recent double-blind study conducted by Active Therapy Professionals concluded that NDC's proprietary pyrrolidine
alkaloid was found to greatly enhance the recruitment and mobilization of stem cells in the body.
This process is mediated by oxidative radicals because treatment of cells with pyrrolidine
dithiocarbamate, a scavenger of such radicals, abolished the NF-kappaB activation (Flory et al.
Endovasc Incorporated (BULLETIN BOARD: EVSC) announced today the results of a two-week study whose objective was to determine if supplementing the diet of mice with very small amounts of its patented and proprietary pyrrolidine
alkaloid resulted in an increase of overall running endurance.