pyroglutamic acid


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5-ox·o·pro·line (Glp),

(ok'kō-prō'lēn),
A keto derivative of proline that is formed nonenzymatically from glutamate, glutamine, and γ-glutamylated peptides; it is also produced by the action of γ-glutamylcyclotransferase; elevated levels of 5-oxoproline are often associated with problems of glutamine or glutathione metabolism.

pyroglutamic acid

[pi′roglootam′ik]
an uncommon amino acid derivative.

pyroglutamic acid

see 5-oxoproline.
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Causes of increased anion gap metabolic acidosis L-lactic acidosis Propylene glycol D-lactic acidosis Aspirin overdose Ketoacidosis Toluene Alcohol Pyroglutamic acid Methanol Ethylene glycol Table 2.
This study focuses on the enzyme human glutaminyl cyclase (GC) because it begins the cyclization of N-terminal glutamine residues into pyroglutamic acid in the hypothalamus, adrenal medulla, and other parts of the brain.
Furthermore, these proteins are more active than ribonucleases currently available even though the proteins of this invention lack an N-terminal pyroglutamic acid, which has been found to be necessary for ribonucleolytic activity.
A pyroglutamic acid (5-oxoproline) level was also markedly elevated (1843 [micro]g/mg of creatinine, 18 times the normal level).
Glutaminyl cyclase cyclizes N-terminal glutamine to pyroglutamic acid in such peptides as TRH.
With a powerful combination of natural and novel ingredients, Prolab([R]) Thermo Fire[TM] contains the following: Raspberry Ketones to help burn fat; Green Tea Extract to help boost metabolism and stimulate thermogenesis; Evodia Extract to help reduce cellular fat production; Caffeine for energy; Guarana, a natural caffeine source; patented Advantra Z([R]) Citrus Aurantium to support metabolic rate when combined with caffeine; L-tyrosine for healthy thyroid function support; Pyroglutamic Acid, Bacopa monniera Extract, Bioperine([R]), and other powerful ingredients.
The surviving glutamine butyl ester is deaminated in acidic solution to a protonated form of pyroglutamic acid butyl ester in the electrospray source of the MS/MS.
This assay detects the N-terminal epitope on gastrin-17, where the N-terminal residue is pyroglutamic acid.
Hawkinsinuria--identification of quinolacetic acid and pyroglutamic acid during an acidotic phase.
1 mmol/L glutamine, lysine, glutamic acid, or pyroglutamic acid were co-injected with L-PA-enriched extracts of pooled plasma samples under the same LC-MS/MS conditions.
2]-terminal pyroglutamic acid residue from peptides such as thyrotropin-releasing hormone or gonadotropin-releasing hormone (GnRH) and artificial substrates (23) (Table 1).
Pyruvic acid overlaps with phthalic, N-acetylaspartic, and glycolic acids; pyroglutamic acid overlaps with 3-hydroxybutyric acid; phenylpyruvic acid overlaps with orotic and hydroxyisovaleric acids; and p-hydroxyphenyl pyruvic and phenyllactic acids overlap with xanthurenic and homogentisic acids.