Causes of increased anion gap metabolic acidosis L-lactic acidosis Propylene glycol D-lactic acidosis Aspirin overdose Ketoacidosis Toluene Alcohol Pyroglutamic acid
Methanol Ethylene glycol Table 2.
This study focuses on the enzyme human glutaminyl cyclase (GC) because it begins the cyclization of N-terminal glutamine residues into pyroglutamic acid
in the hypothalamus, adrenal medulla, and other parts of the brain.
Furthermore, these proteins are more active than ribonucleases currently available even though the proteins of this invention lack an N-terminal pyroglutamic acid
, which has been found to be necessary for ribonucleolytic activity.
A pyroglutamic acid
(5-oxoproline) level was also markedly elevated (1843 [micro]g/mg of creatinine, 18 times the normal level).
Glutaminyl cyclase cyclizes N-terminal glutamine to pyroglutamic acid
in such peptides as TRH.
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The surviving glutamine butyl ester is deaminated in acidic solution to a protonated form of pyroglutamic acid
butyl ester in the electrospray source of the MS/MS.
This assay detects the N-terminal epitope on gastrin-17, where the N-terminal residue is pyroglutamic acid
Hawkinsinuria--identification of quinolacetic acid and pyroglutamic acid
during an acidotic phase.
1 mmol/L glutamine, lysine, glutamic acid, or pyroglutamic acid
were co-injected with L-PA-enriched extracts of pooled plasma samples under the same LC-MS/MS conditions.
2]-terminal pyroglutamic acid
residue from peptides such as thyrotropin-releasing hormone or gonadotropin-releasing hormone (GnRH) and artificial substrates (23) (Table 1).
Pyruvic acid overlaps with phthalic, N-acetylaspartic, and glycolic acids; pyroglutamic acid
overlaps with 3-hydroxybutyric acid; phenylpyruvic acid overlaps with orotic and hydroxyisovaleric acids; and p-hydroxyphenyl pyruvic and phenyllactic acids overlap with xanthurenic and homogentisic acids.