Increased expression of the NOD-like receptor family, pyrin
domain containing 3 inflammasome in dermatomyositis and polymyositis is a potential contributor to their pathogenesis.
For example, although it was not detected by GWASs, a SNP in the 3'-UTR of NLR family, pyrin
domain containing 3 (NLRP3), which controls the activation of inflammatory caspase-1 by forming NLRP3-inflammasomes, was found to be significantly associated with susceptibility to Japanese food-induced anaphylaxis.
The mutations, on MEFV gene encoding pyrin
protein, are thought to be the cause of FMF.
4] The Mediterranean Fever (MEFV) gene, associated with FMF, is located on chromosome 16 and encodes a 781-amino-acid protein termed pyrin
The potential mechanism maybe that allopurinol inhibit p38 MAPK/ NOD-like receptor pyrin
domain-containing 3 inflammasome pathway activation (Wang et al.
Nanoparticles activate the NLR pyrin
domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1 [alpha] and IL-1[beta].
7] The largest group contains 14 members which have N-terminal pyrin
Cryopyrinopathies are genetically determined diseases caused by mutations in NLRP3 (NLR family, pyrin
domain containing 3) that manifest by cold-induced urticaria, periodic fever, and arthritis.
The protein encoded by MEFV gene has been named pyrin
for its role in anti-pyrexia.
Activation of the pyrin
inflammasome by intracellular Burkholderia cenocepacia," Journal of Immunology, vol.
Interestingly, the main pathways involved in cellular senescence regulation, such as the NF-[kappa]B, the mechanistic target of rapamycin (mTOR), and the interleukin-1/NLR family pyrin
domain containing 3 (IL-1/NLRP3) inflammasome pathways, are master modulators of the aging rate [27-29].
Other stories to feature include the rescues of the HMHS Rohilla in 1914, SS Glenravel in 1915, the Ponus in 1916, the SS Alondra in 1916 and the Pyrin
and Fernebo in 1917.