pyrimidine dimer


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py·rim·i·dine di·mer

a product of ultraviolet radiation of pyrimidines in nucleic acids; most frequently thymidine dimers.
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Thus a single pyrimidine dimer, if left unrepaired, is sufficient to completely eliminate the expression of a transcriptional unit.
Therefore, genetic analysis of pyrimidine dimer (T=T) formation in D.
Simultaneous establishment of monoclonal antibodies specific for either cyclobutane pyrimidine dimer or (6-4) photoproduct from the same mouse immunized with ultraviolet-irradiated DNA.
Ultraviolet radiation disrupts the structure of DNA by causing a chemical reaction that hooks together two distinct bases, forming a so-called pyrimidine dimer.
This observation strongly suggests that humans suffering from XP are probably prone to cancer in organs other than the skin given sufficient exposure to chemical carcinogens--a result to be expected, based on the observation that NER deals with multiple types of base damage in DNA, not just pyrimidine dimers.
Shorter telomere length has been linked to an increase risk of some cancers [1,2] and, in fact, UVB exposure creates a high frequency of pyrimidine dimers in telomeric regions.
Enzymatic photoreactivation is a direct mechanism to repair UV-induced cyclobutane pyrimidine dimers.
The sun's ultraviolet light creates these so-called pyrimidine dimers, which prevent proper DNA replication and can lead to skin cancer and other malignancies.
We also showed that treatment of GTP to human skin prevents UVB-induced cyclobutane pyrimidine dimers formation, which are considered to be mediators of UVB-induced immune suppression and skin cancer induction.
Reagentas cyclobutane pyrimidine dimers determination after UV-irradiation preliminary points to 1 Coll .