Thus a single pyrimidine dimer, if left unrepaired, is sufficient to completely eliminate the expression of a transcriptional unit.
Therefore, genetic analysis of pyrimidine dimer (T=T) formation in D.
Simultaneous establishment of monoclonal antibodies specific for either cyclobutane pyrimidine dimer
or (6-4) photoproduct from the same mouse immunized with ultraviolet-irradiated DNA.
Ultraviolet radiation disrupts the structure of DNA by causing a chemical reaction that hooks together two distinct bases, forming a so-called pyrimidine dimer
This observation strongly suggests that humans suffering from XP are probably prone to cancer in organs other than the skin given sufficient exposure to chemical carcinogens--a result to be expected, based on the observation that NER deals with multiple types of base damage in DNA, not just pyrimidine dimers
A decrease in pyrimidine dimers
, in 18 out of 19 patients, for an average reduction of 53%.
Shorter telomere length has been linked to an increase risk of some cancers [1,2] and, in fact, UVB exposure creates a high frequency of pyrimidine dimers
in telomeric regions.
Enzymatic photoreactivation is a direct mechanism to repair UV-induced cyclobutane pyrimidine dimers
The sun's ultraviolet light creates these so-called pyrimidine dimers
, which prevent proper DNA replication and can lead to skin cancer and other malignancies.
We also showed that treatment of GTP to human skin prevents UVB-induced cyclobutane pyrimidine dimers
formation, which are considered to be mediators of UVB-induced immune suppression and skin cancer induction.
22 Cyclobutane pyrimidine dimers
as UV-induced DNA lesions (Marcus G.
Reagentas cyclobutane pyrimidine dimers
determination after UV-irradiation preliminary points to 1 Coll .