pyridoxine dependency

pyridoxine dependency

(pir″ĭ-dok′sēn″, sĕn) [ pyrid(ine) + ox(ygen) + -ine]
A rare autosomal recessive cause of neonatal seizures. The disorder requires lifelong supplementation of pyridoxine (vitamin B6).
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6 Hypocalcaemia is the commonest metabolic disorder followed by hypoglycemia), intracranial bleed, brain malformation, inborn errors of metabolism (urea cycles defects, mitochondrial abnormalities), tetanus, kernicterus and pyridoxine dependency.
So, pyridoxines may be added to the management in spite of the rare case of pyridoxine dependency, which may cause refractory seizures.