Closely monitor patients for signs and symptoms of serious events such as pyrexia
, headache, nausea, asthenia, hypotension, increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased total bilirubin (TBILI), disseminated intravascular coagulation (DIC), capillary leak syndrome (CLS), and hemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS).
Leading causes of classic pyrexia
of unknown origin Infection Neoplasms Tuberculosis Lymphoma Occult bacterial abscess Renal carcinoma Endocarditis Atrial myxoma Brucellosis Infection Connective tissue Tuberculosis Still's disease Occult bacterial abscess Variants of rheumatoid arthritis Endocarditis Systemic lupus erythematosus Brucellosis Temporal arteritis Polymyalgia rheumatica Infection Other (geographical) Tuberculosis Familial Mediterranean fever Occult bacterial abscess Kikuchi-Fujimoto disease Endocarditis Melioidosis Brucellosis Pyrexia
of unknown origin defined as temperature >38.
Antipyretic activity of AVELE in the yeast-induced mice pyrexia
The percent effect of PA in yeast induced pyrexia
test at various doses is demonstrated in Fig.
Secondly: in our experience, the most common cause by far of abdominal lymphadenopathy in HIV-infected patients with pyrexia
is tuberculous lymphadenitis.
In the integrated analysis, the most commonly reported adverse events were asthenic conditions (including fatigue, malaise, and weakness) (64%), nausea (55%), diarrhea (52%), constipation (41%), peripheral neuropathy NEC (including peripheral sensory neuropathy and peripheral neuropathy aggravated) (39%), thrombocytopenia and appetite decreased (including anorexia) (each 36%), pyrexia
(34%), vomiting (33%), and anemia (29%).
Infection was defined as cases of confirmed diagnosis of infection and also those treated with antibiotics for any reason, including presumptive infection based on the presence of prolonged bleeding, abdominal pain, offensive discharge and/or pyrexia
Exposure to isolated fever was defined as maternal intrapartum fever of 38[degrees] C or greater, or ICD-9 diagnosis of maternal intrapartum pyrexia
In Xeloda monotherapy for metastatic colorectal cancer, the most common adverse events were anemia (80%), diarrhea (55%), hand-foot syndrome (54%), hyperbilirubinemia (48%), nausea (43%), fatigue/weakness (42%), abdominal pain (35%), dermatitis (27%), vomiting (27%), appetite decreased (26%), stomatitis (25%), pyrexia
(18%), edema (15%), constipation (14%), dyspnea (14%), neutropenia (13%), pain (12%), back pain (10%), and headache (10%).
3 mg/m(2)/dose in phase II studies, the most commonly reported adverse events were asthenic conditions (65 percent), nausea (64 percent), diarrhea (51 percent), decreased appetite including anorexia (43 percent), constipation (43 percent), thrombocytopenia (43 percent), peripheral neuropathy (37 percent), pyrexia
(36 percent), vomiting (36 percent), and anemia (32 percent).
24) Likewise, acetaminophen or a nonsteroidal anti-inflammatory drug might be necessary to treat pyrexia
and/or lymphadenopathic pain.
The most common adverse reactions observed in clinical trials (frequency 10 percent of subjects) were pyrexia
, headache, cough, nasopharyngitis, vomiting, arthralgia, and limb injury.