In 1993, zaleplon (Sonata) was the first pyrazolopyrimidine investigated for clinical use as a hypnotic.
However, future research may reveal that all imidazopyridine, pyrazolopyrimidine, and cyclopyrrolone hypnotics can induce these parasomnias.
Interestingly, recently developed classes of hypnotic drugs - the imidazopyridines, pyrazolopyrimidines, and cyclopyrolones - can similarly cause sleep walking and other sleep behaviors (e.
The '328 patent relates to the use of pyrazolopyrimidine
and 7-deazapurine nucleosides as replacements for the natural guanosine (G) nucleoside in nucleic acid probes.
Lader of the Institute of Psychiatry, London, reported the results of two open-label trials of zaleplon, a novel pyrazolopyrimidine
sleep medication that binds selectively and with low affinity to the brain benzodiazepine type 1 [gamma]-aminobutyric acid-receptor complex.
Pyrazolopyrimidine substances have been synthesized since the 1970s.
Interestingly, recently developed classes of hypnotic drugs--the imidazopyridines, pyrazolopyrimidines, and cyclopyrolones--can similarly cause sleep walking and other sleep behaviors (e.
The '991 patent relates to a process for the synthesis of pyrazolopyrimidine
The first poster, entitled "Subtype Selective Modulation of GABAA Receptor by Ocinaplon, an Anxioselective Pyrazolopyrimidine
," describes the ongoing collaborative research between DOV and investigators in the department of pharmacology at Boston University School of Medicine investigating the mechanism of action of Ocinaplon.