pyrazolopyrimidine


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pyrazolopyrimidine

(pī-rāz'ōp;ēr-i-di-mēn),
Member of a class of sedative hypnotics that potentiate GABAA receptor function.
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In 1993, zaleplon (Sonata) was the first pyrazolopyrimidine investigated for clinical use as a hypnotic.
However, future research may reveal that all imidazopyridine, pyrazolopyrimidine, and cyclopyrrolone hypnotics can induce these parasomnias.
Interestingly, recently developed classes of hypnotic drugs - the imidazopyridines, pyrazolopyrimidines, and cyclopyrolones - can similarly cause sleep walking and other sleep behaviors (e.
The '328 patent relates to the use of pyrazolopyrimidine and 7-deazapurine nucleosides as replacements for the natural guanosine (G) nucleoside in nucleic acid probes.
Lader of the Institute of Psychiatry, London, reported the results of two open-label trials of zaleplon, a novel pyrazolopyrimidine sleep medication that binds selectively and with low affinity to the brain benzodiazepine type 1 [gamma]-aminobutyric acid-receptor complex.
Lader of the Institute of Psychiatry London, reported the results of two open-label trials of zaleplon, a novel pyrazolopyrimidine sleep medication that binds selectively and with low affinity to the brain benzodiazepine type 1 gammaaminobutyric acid-receptor complex.
Pyrazolopyrimidine substances have been synthesized since the 1970s.
Interestingly, recently developed classes of hypnotic drugs--the imidazopyridines, pyrazolopyrimidines, and cyclopyrolones--can similarly cause sleep walking and other sleep behaviors (e.
The '991 patent relates to a process for the synthesis of pyrazolopyrimidine nucleoside phosphoramidites.