Furthermore, we show that purine metabolism
pathway genes coordinate with ARGs; this novel discovery supports future studies on AIDS therapy using purine derivatives.
A second patent application covers the use of uridine and TAU for the correction of defects in purine metabolism
which produce the symptoms of autism or pervasive developmental disorder.
It acts upstream of xanthine oxidase (XO) in the purine metabolism
pathway to reduce new formation of uric acid in patients with gout.
Pathways involved in 9 heritable metabolic disorders of purine metabolism
and 7 heritable metabolic disorders of pyrimidine metabolism are depicted in Fig.
It acts upstream of xanthine oxidase in the purine metabolism
pathway to reduce sUA in patients with gout and has a mechanism of action that complements xanthine oxidase inhibitors, such as allopurinol and febuxostat, in reducing uric acid production.
We hypothesized that gout patients may have a different profile of purine precursors than do asymptomatic people with hyperuricemia and that concentrations of these compounds may reflect disorders of purine metabolism