purine analogue


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analogue

 [an´ah-log]
1. a part or organ having the same function as another, but of different evolutionary origin.
2. a chemical compound having a structure similar to that of another but differing from it in respect to a certain component; it may have similar or opposite action metabolically. Also spelled analog.
nucleoside analogue a structural analogue of a nucleoside, a category that includes both purine analogues and pyrimidine analogues.
purine analogue a structural analogue of one of the purine bases(purine, adenine, or guanine); mercaptopurine and thioguanine are used as antineoplastics and azathioprine is an immunosuppressive. The antiviral agent vidarabine is an analogue of the adenine nucleoside adenosine.
pyrimidine analogue a structural analogue of one of the pyrimidine bases(cytosine, thymine, or uracil); fluorouracil and cytarabine are important antineoplastic agents.

purine analogue

Pharmacology A therapeutic that mimics the chemical structure of purine; in pathologic conditions, where there is ↑ production of DNA, PAs compete with normal purines–guanine and adenine and are incorporated in the DNA of mitotically active 'rogue' cells, eventually destroying them. See 6-MP, Nucleoside analogues.