purine


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Related to purine: uric acid, low purine diet

purine

 [pu´rēn]
a heterocyclic compound that is the nucleus of the purine bases such as adenine and guanine (which occur in DNA and RNA), and xanthine and hypoxanthine.

pur·ine (Pur),

(pyūr'ēn, -rin),
The parent substance of adenine, guanine, and other naturally occurring purine "bases."

purine

/pu·rine/ (pūr´ēn) a compound, C5H4N4, not found in nature, but variously substituted to produce a group of compounds, purines or purine bases, which include adenine and guanine found in nucleic acids and xanthine and hypoxanthine.

purine

(pyo͝or′ēn′)
n.
1. A double-ringed, crystalline organic base, C5H4N4, that is the parent compound of a large group of biologically important compounds.
2. Any of a group of substituted derivatives of purine, including the nitrogen bases adenine and guanine, which are components of nucleic acids. Uric acid, caffeine, theobromine, and theophylline are also purines.

purine

[pyo̅o̅′rēn]
Etymology: L, purus, pure, urina, urine
any one of a large group of nitrogenous compounds. Purines are produced as end products in the digestion of certain proteins in the diet, but some are synthesized in the body. Purines are also present in many medications and other substances, including caffeine, theophylline, and various diuretics, muscle relaxants, and myocardial stimulants. Hyperuricemia may develop in some people as a result of an inability to metabolize and excrete purines. A low-purine diet or a purine-free diet may be required. Foods that are high in purines include anchovies and sardines; sweetbreads, liver, kidneys, and other organ meats; legumes; and poultry. The foods lowest in purine content include eggs, fruit, cheese, nuts, sugar, gelatin, and vegetables other than legumes.

pu·rine

(pyūr'ēn)
The parent substance of adenine, guanine, and other naturally occurring so-called purine bases; not known to exist as such in mammals.

purine

one of two types of base found in NUCLEIC ACIDS, having a double ring structure; see ADENINE and GUANINE. Purines always pair with PYRIMIDINES in the two strands of DNA, ensuring a parallel-sided molecule.

Purine

A white crystalline substance that is one of the building blocks of DNA. Uric acid is produced when purine is broken down in the body.
Mentioned in: Gout, Uric Acid Tests

purine

a heterocyclic compound that is the nucleus of the purine bases (or purines) such as adenine and guanine, which occur in DNA and RNA, and xanthine and hypoxanthine. All living cells contain purines as purine nucleotides. They can be synthesized using amino acids, or by salvage of dietary or endogenous nucleotides derived from cell wastage.

A purine
adenine.
low purine diet
one with a low content of organ meats, seafood, beans, lentils, peas and spinach; used in the dietary management of xanthine or urate uroliths in dogs.
purine nucleoside phosphorylase
a transferase enzyme that acts in the degradation of nucelotides and nucleic acids.
References in periodicals archive ?
0 g/kg of the total excreted purine derivatives and a very significant percentage was considered for the quantification of TP and absorbed purines (Table 4).
By the end of the 1970s, Burnstock was proved correct, and there are now hundreds of scientists around the world researching the importance of purine receptors in a variety of diseases.
Then the amounts of uric acid and allantoin in each sample were added to each other to come up with the total of purine derivatives (mmol/day).
For cases where dietary adaptation just isn't enough to prevent further relapses, your doctor can prescribe the drug Allopurinol, which prevents the break down of purines into uric acid and, when taken daily, is effective at preventing recurrent attacks in gout-prone individuals.
Increased levels of purine (a product of DNA) can raise the level of uric acid in the blood.
Certain foods and beverages contain compounds called purines that break down in the body to form the uric acid that causes gout.
BioCryst's lead product candidate, forodesine hydrochloride (BCX-1777, or forodesine), an inhibitor of purine nucleoside phosphorylase (PNP), is currently in a Phase IIa trial for patients with T-cell malignancies with additional Phase I/II trials planned for hematologic malignancies, and for cutaneous T-cell lymphoma (CTCL).
To pin down the link between gout and dietary purine, Hyon K.
This chemical scaffold differentiates these compounds from Cyclacel's CYC200 purine series, which generated Cyclacel's first clinical candidate, CYC202, now undergoing Phase II trials.
5% abv `happo-shu'--a low malt lager-style beer--which is marketed as low in purine.
Results: Exercise-induced increases in plasma markers of purine catabolism (hypoxanthine, xanthine oxidase and serum uric acid) and circulating cytosolic proteins (myoglobin, fatty acid-binding protein, and creatine kinase) were significantly attenuated by LCLT.
Irvine, CA; 949- 788-6700) announced that the company has been allowed a United States patent covering the use of purine derivates, such as Neotrofin, to selectively activate or depress genes encoding for molecules such as neurotrophic factors.