pure red cell aplasia

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pure red cell a·pla·si·a

a transitory arrest of red blood cell production that may occur in the course of a hemolytic anemia, often preceded by infection, or as a complication of certain drugs; if the arrest persists, severe anemia may result.
See also: congenital hypoplastic anemia.

pure red cell aplasia

Hematology A type of anemia caused by selective depletion of erythroid cells
Pure red cell aplasia types
Acute Aplastic crisis A condition often preceded by viral gastroenteritis, pneumonitis, primary atypical pneumonia, mumps, viral hepatitis, pregnancy and drug toxicity Clinical Malaise, pallor and other symptoms of a chronic, compensated hemolyzing process Treatment The only effective modality is discontinuance of inculpated drug, if identified
Chronic Either
1.Congenital Diamond-Blackfan disease A condition due to a ↓ in erythrocyte stem cells with ↓ colony-forming units and burst-forming units and a poor response to erythropoietin Treatment Transfusions, corticosteroids or.
2. Acquired 30-50% of chronic acquired PRCA is associated with thymoma, as well as rheumatoid arthritis, lupus erythematosus, chronic active hepatitis, hemolytic anemia and CLL  

pure red cell aplasia

A severe failure of production of red blood cells by the bone marrow with normal production of other blood cells. The result is a temporary or persistent severe anaemia. The condition may be caused by some virus infections, some drugs, cancers, rheumatoid arthritis and systemic lupus erythematosus.


defective development or complete absence of an organ or tissue due to failure of development.

aplasia cutis
see epitheliogenesis imperfecta.
pure red cell aplasia
selective depression of erythropoiesis with anemia resulting.
segmental aplasia
aplasia of a segment of an organ, e.g. uterus.
References in periodicals archive ?
Thus, he was diagnosed with pure red cell aplasia secondary to parvovirus B19 infection, and this was actually his initial manifestation of HIV infection.
In immunocompromised patients, persistent infection can cause pure red cell aplasia and chronic severe anemia.
Pure red cell aplasia is characterized by an isolated decrease in red cell production by the bone marrow.
It is thought that pure red cell aplasia secondary to parvovirus B19 develops in immunocompromised patients because they are unable to produce effective neutralizing antibodies and thus are unable to effectively clear the viral infection.
Dessypris EN: Aplastic anemia and pure red cell aplasia.
Sawada K, Hirokawa M, Fujishima N: Diagnosis and management of acquired pure red cell aplasia.
Pure red cell aplasia caused by Parvovirus B19 infection in solid organ transplant recipients: a case report and review of literature.
Parvovirus B 19-induced persistent pure red cell aplasia in a child with T-cell immunodeficiency.
Pure red cell aplasia following ABO-incompatible bone marrow transplantation: response to erythropoietin.
Delayed donor red cell chimerism and pure red cell aplasia following major ABO-incompatible nonmyeloablative hematopoietic stem cell transplantation.
Pure red cell aplasia following peripheral stem cell transplantation: complete response to a short course of high-dose recombinant human erythropoietin.
Resistant pure red cell aplasia after allogeneic stem cell transplantation with major ABO mismatch treated by escalating dose donor leukocyte infusion.