punched-out

punched-out

adjective Pertaining to rounded, well-circumscribed often multiple lesions seen in various sites GI disease Punched-out lesions seen in the stomach by endoscopy usually correspond to benign gastric ulcers; they are well-demarcated with a sharply-defined wall and a smooth base. Cf Heaped-up Imaging Rounded, sharply demarcated, cyst-like spaces without sclerotic margins, characteristic of myeloma of the diploë of the skull, causing sharply demarcated 'holes.', due to osteoclast-activating factor secretion in plasma cells; punched-out bony defects also occur in well-circumscribed mutilating sarcoidosis of the small hand bones, chronic gouty arthritis as chondroosseous lesions that communicate with the urate 'crust' through cartilaginous defects, childhood hypophosphatasia, leukemic foci in skull, TB. See Myeloma.