Immunohistochemistry in a significant portion of babies with the syndrome observed decrease in expression of surfactant protein B, probably due to qualitative changes in pulmonary surfactant
On that point Brubaker was most impressed with Anthony Colucci's pulmonary surfactant
studies, which, he wrote, came close to understanding the cause, or mechanism, of how smoking triggers emphysema.
KEY WORDS: Neonate, Pulmonary surfactant
, Respiratory distress syndrome.
The claims of the patent provide coverage for synthetic pulmonary surfactant
compositions comprising of a combination of a proprietary synthetic peptide and various lipids.
As a quick reminder, respiratory distress syndrome (RDS) of the newborn is the seventh most common cause of perinatal mortality in the United States, and it is caused by a deficiency of pulmonary surfactant
ABCA3 as a lipid transporter in pulmonary surfactant
Current studies are investigating known polymorphisms in the pulmonary surfactant
proteins important to host defense and in the Th2 cytokines, such as IL-13, that drive the asthma response.
Also referred to as hyaline membrane disease, respiratory distress syndrome results from an insufficient amount of pulmonary surfactant
that is produced by the neonatal lung and released into the amniotic fluid.
A common feature of respiratory distress is a change in pulmonary surfactant
, which is the surface lining of the lungs and is comprised of a complex mixture of phospholipids, neutral lipids and proteins.
Currently, treatment schemes for improving ventilation of newborns with respiratory failure include high-frequency oscillatory ventilation, the supplement of pulmonary surfactant
, nitric oxide (NO) inhalation, liquid ventilation and extracorporeal membrane oxygenation.
10) demonstrated that both LDL and HDL cholesterol stimulate primary cultures of type II cells to secrete phosphatidylcholine, the major phospholipid component of pulmonary surfactant
It is during this stage that type II pneumocytes increase production of pulmonary surfactant
Lung development continues for approximately eight years.