The identification of fat attenuation within a smooth or lobulated SPN on thin-section CT is diagnostic of a pulmonary hamartoma (Figure 6).
These are central, laminated, or diffuse calcification as seen within granulomas, and popcorn calcification seen in pulmonary hamartomas (Figure 3).
This factor is known to play a significant role in the frequent misdiagnoses of pulmonary hamartoma
(18) and in rare cases of pulmonary sequestration (15); in both lesions, the culprit is the abundant benign cohesive epithelium often misinterpreted as well-differentiated adenocarcinoma.
Benign lung tumors in the differential diagnosis include clear cell tumor, pulmonary hamartoma
, and hemangioma.
Hematoxylin-eosin-stained slides of all 38 cases of pulmonary hamartoma were reviewed for the presence of villus papillary projections or placenta-like structures.
Thirty-eight cases of pulmonary hamartoma resected by wedge resection or lobectomy were identified from departmental records.
They contend that lipomatosis may be differentiated from a pulmonary hamartoma.
We herein describe a clear association of PT with pulmonary hamartoma.
In conclusion, we demonstrate that PT is a pattern frequently associated with pulmonary hamartoma.
Pulmonary hamartomas are common benign tumors considered to originate from primitive mesenchymal tissue.
While a hamartoma is defined as disordered growth of tissues normally present within the organ, pulmonary hamartomas are clonal proliferations and therefore neoplastic.
Pulmonary hamartomas contain at least 2 benign/mature mesenchymal tissues, one of which is often cartilage (Figure 3, B).