pulmonary delivery system

pulmonary delivery system

A system designed for noninvasive, systemic delivery of therapeutic macromolecules (e.g., insulin, tobramycin, leuprolide, dronabinol, PTH) via alveolar absorption.

Pros
Pulmonary route offers the highest bioavailability of any noninvasive route and facilitates more rapid drug absorption in the circulation compared with subcutaneous injection.
 
Cons
Administration of insulin, the pilot for the pulmonary delivery platform, resulted in inconsistent serum levels. It proved too expensive for the market.
References in periodicals archive ?
Inhale's pulmonary delivery system administers fine, dry aerosol powders to the deep lung.
Stephen Mucelli joins the firm from a pulmonary delivery system technology-manufacturing center, where he served as a Quality Assurance Mechanical Drafter.
began a 100-patient, 21-day Phase 2 clinical trial in asthmatic patients investigating aerosolized HCQ using Aradigm's AERx(R) pulmonary delivery system.
The goal of this study is to prove that sexual dysfunction drugs may be delivered using a pulmonary delivery system in a clinically effective manner using our patented device.
The Phase I study was conducted using the advanced AERx(R) pulmonary delivery system by Aradigm Corp.
These studies will use the advanced AERx(R) pulmonary delivery system by Aradigm Corp.
Our areas of focus include: controlled, extended-release of injectable drugs utilizing our ProLease(R) and Medisorb(R) delivery systems and the development of inhaled pharmaceutical products based on our AIR(R) pulmonary delivery system.
16: Maturity of electronic active delivery platforms in transmembrane and pulmonary delivery systems 72
Pulmonary delivery systems have the inside track, with intranasal, oral, buccal, and transdermal delivery technologies also in pursuit of this $5 billion a year market.