pulmonary delivery system

pulmonary delivery system

A system designed for noninvasive, systemic delivery of therapeutic macromolecules (e.g., insulin, tobramycin, leuprolide, dronabinol, PTH) via alveolar absorption.

Pros
Pulmonary route offers the highest bioavailability of any noninvasive route and facilitates more rapid drug absorption in the circulation compared with subcutaneous injection.
 
Cons
Administration of insulin, the pilot for the pulmonary delivery platform, resulted in inconsistent serum levels. It proved too expensive for the market.
References in periodicals archive ?
Inhale's pulmonary delivery system administers fine, dry aerosol powders to the deep lung.
Stephen Mucelli joins the firm from a pulmonary delivery system technology-manufacturing center, where he served as a Quality Assurance Mechanical Drafter.
Clinical trials examining this novel pulmonary delivery system in patients with inflammatory lung diseases will be of interest.
began a 100-patient, 21-day Phase 2 clinical trial in asthmatic patients investigating aerosolized HCQ using Aradigm's AERx(R) pulmonary delivery system.
To deliver ALN-RSV01 to the site of infection, the RNA therapeutic is being administered as an aerosol in a highly efficient pulmonary delivery system, an optimized eFlow platform nebulizer, with high drug output, optimized droplet size, and low residual drug loss.
The goal of this study is to prove that sexual dysfunction drugs may be delivered using a pulmonary delivery system in a clinically effective manner using our patented device.
To deliver ALN-RSV01 to the site of infection, the siRNA is being administered as an aerosol in a highly efficient pulmonary delivery system, the optimized eFlow(R) electronic nebulizer, with high drug output, optimized droplet size, and low residual drug loss.
The Phase I study was conducted using the advanced AERx(R) pulmonary delivery system by Aradigm Corp.
These studies will use the advanced AERx(R) pulmonary delivery system by Aradigm Corp.
The Company's AERx(R) advanced pulmonary delivery system and its Intraject(R) needle-free delivery system provide leading pharmaceutical and biotechnology partners with effective solutions for product self- administration.
Our areas of focus include: controlled, extended-release of injectable drugs utilizing our ProLease(R) and Medisorb(R) delivery systems and the development of inhaled pharmaceutical products based on our AIR(R) pulmonary delivery system.
APT and Aradigm are developing this aerosolized formulation of the anti-inflammatory agent HCQ in Aradigm's AERx pulmonary delivery system as a new class of treatment for asthma and chronic obstructive pulmonary disease.