pulmonary Langerhans cell histiocytosis


Also found in: Acronyms.

pulmonary Langerhans cell histiocytosis

A condition seen almost exclusively in cigarette smokers, which is characterised by proliferation of Langerhans cells. Early lesions have a centrilobular distribution and a mixed inflammatory-cell infiltrate consisting of lymphocytes, eosinophils, neutrophils, plasma cells, pigmented macrophages and fibroblasts. With time, the inflammation subsides and fibrotic scars predominate with enlarged and distorted airspaces. The characteristic histology can be confirmed by CD1a staining.
References in periodicals archive ?
Pulmonary Langerhans cell histiocytosis and other pulmonary histiocytic diseases: a review.
Potential Etiologies of Chronic Bronchiolitis (a) Infection Collagen vascular disease Posttransplantation graft-versus-host disease Inflammatory bowel disease-related small airways disease Hypersensitivity pneumonitis Pulmonary Langerhans cell histiocytosis Aspiration pneumonia Diffuse panbronchiolitis Distal to bronchiectasis Lymphoproliferative disorders Local inflammatory reaction such as with middle lobe syndrome Asthma Chronic obstructive pulmonary disease Idiopathic (a) Data were derived from Cagle et al.

Full browser ?