psychosurgery

Psychosurgery 

Definition

Psychosurgery involves severing or otherwise disabling areas of the brain to treat a personality disorder, behavior disorder, or other mental illness. Modern psychosurgical techniques target the pathways between the limbic system (the portion of the brain on the inner edge of the cerebral cortex) that is believed to regulate emotions, and the frontal cortex, where thought processes are seated.

Purpose

Lobotomy is a psychosurgical procedure involving selective destruction of connective nerve fibers or tissue. It is performed on the frontal lobe of the brain and its purpose is to alleviate mental illness and chronic pain symptoms. The bilateral cingulotomy, a modern psychosurgical technique which has replaced the lobotomy, is performed to alleviate mental disorders such as major depression, bipolar disorder, or obsessive-compulsive disorder (OCD), which have not responded to psychotherapy, behavioral therapy, electroshock, or pharmacologic treatment. Bilateral cingulotomies are also performed to treat chronic pain in cancer patients.

Precautions

Psychosurgery should be considered only after all other non-surgical psychiatric therapies have been fully explored. Much is still unknown about the biology of the brain and how psychosurgery affects brain function.

Description

Psychosurgery, and lobotomy in particular, reached the height of use just after World War II. Between 1946 and 1949, the use of the lobotomy grew from 500 to 5,000 annual procedures in the United States. At that time, the procedure was viewed as a possible solution to the overcrowded and understaffed conditions in state-run mental hospitals and asylums. Known as prefrontal or transorbital lobotomy, depending on the surgical technique used and area of the brain targeted, these early operations were performed with surgical knives, electrodes, suction, or ice picks, to cut or sweep out portions of the frontal lobe.

Today's psychosurgical techniques are much more refined. Instead of going in "blind" to remove large sections on the frontal lobe, as in these early operations, neurosurgeons use a computer-based process called stereotactic magnetic resonance imaging to guide a small electrode to the limbic system (brain structures involved in autonomic or automatic body functions and some emotion and behavior). There an electrical current burns in a small lesion [usually 0.5 in (1.3 cm) in size]. In a bilateral cingulotomy, the cingulate gyrus, a small section of brain that connects the limbic region of the brain with the frontal lobes, is targeted. Another surgical technique uses a non-invasive tool known as a gamma knife to focus beams of radiation at the brain. A lesion forms at the spot where the beams converge in the brain.

Preparation

Candidates for cingulotomies or other forms of psychosurgery undergo a rigorous screening process to ensure that all possible non-surgical psychiatric treatment options have been explored. Psychosurgery is only performed with the patient's informed consent.

Aftercare

Ongoing behavioral and medication therapy is often required in OCD patients who undergo cingulotomy. All psychosurgery patients should remain under a psychiatrist's care for follow-up evaluations and treatment.

Risks

As with any type of brain surgery, psychosurgery carries the risk of permanent brain damage, though the advent of non-invasive neurosurgical techniques, such as the gamma knife, has reduced the risk of brain damage significantly.

Normal results

In a 1996 study at Massachusetts General Hospital, over one-third of patients undergoing cingulotomy demonstrated significant improvements after the surgery. And, in contrast to the bizarre behavior and personality changes reported with lobotomy patients in the 1940s and 1950s, modern psychosurgery patients have demonstrated little post-surgical losses of memory or other high level thought processes.

Resources

Organizations

Massachusetts General Hospital. Functional and Stereotactic Neurosurgery Cingulotomy Unit. Fruit St., Boston, MA 02114. (617) 726-2000. 〈http://neurosurgery.mgh.harvard.edu/cingulot.htm〉.

National Alliance for the Mentally Ill (NAMI). Colonial Place Three, 2107 Wilson Blvd., Ste. 300, Arlington, VA 22201-3042. (800) 950-6264. http://www.nami.org.

National OCD Headquarters. P.O. Box 70, Milford, CT 06460. (203) 878-5669.

Key terms

Gamma knife — A surgical tool that focuses beams of radiation at the head, which converge in the brain to form a lesion.

Lesion — Any discontinuity of tissue. Often a cut or wound.

Limbic system — A portion of the brain on the inner edge of the cerebral cortex that is thought to regulate emotions.

Psychosurgery — Brain surgery performed to alleviate chronic psychological conditions such as obsessive-compulsive disorder (OCD), depression, and bipolar disorder.

Stereotactic technique — A technique used by neurosurgeons to pinpoint locations within the brain. It employs computer imaging to create an external frame of reference.

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psychosurgery /psy·cho·sur·gery/ (-ser´jer-e) brain surgery performed for treatment of psychiatric disorders.psychosur´gical

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psy·cho·sur·ger·y (sk-sûrj-r)

n.

Brain surgery used to treat severe, intractable mental or behavioral disorders.

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psycho·surgeon (-sûrjn) n.

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psychosurgery

[-sur′jərē]

Etymology: Gk, psyche + cheirourgia

surgical interruption of certain nerve pathways in the brain, performed to treat selected cases of chronic unremitting anxiety, agitation, or obsessional neuroses. Modern psychotherapeutic drugs have replaced psychosurgery in most cases. Psychosurgery is performed when the condition is severe and when alternative treatments, such as psychotherapy, drugs, and electroshock, have proved ineffective. The procedure may be a limited prefrontal lobotomy, in which connecting fibers in the frontal region are cut, or a modified bifrontal tractotomy, in which nerve tracts of the brainstem are severed. Light general anesthesia is given. Postoperative nursing care includes observation for signs of leakage of cerebrospinal fluid. A marked alteration of personality is unavoidable. Various cognitive and affective functions also are affected, depending on the location of the induced lesion, the extent of destruction of nerve tissue, and the age, sex, and condition of the patient.

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psychosurgery [si″ko-ser´jer-e]

brain surgery done to treat psychiatric disorders. adj., adj psychosur´gical.

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psychosurgery

neurosurgery for the purpose of altering behavior. See olfactory tractotomy.

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psychosurgery

Neurosurgery Neurosurgery intended to alleviate psychiatric Sx, by selectively destroying neural tracts; psychosurgery includes radioactive 90Yt implants in the substantia innominata, cryoprobes, coagulation, proton beams and ultrasonic waves; psychosurgery is rarely performed, as it must be established that a Pt is unresponsive to all other therapies and that the condition is chronic–ie, > 3 yrs duration; significant improvement is reported in 60% of carefully selected Pts; in 3%, the Sx worsen after the procedure; the measurable IQ may ↑, given the ↑ ability to concentrate and memorize, while distraction is minimized Complications 1%; include infections, hemorrhage, seizures. Cf Psychic surgery.