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pseudotype

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pseudotype
phenotypic mixing in retroviruses results in a genome from a parent with a defective envelope, contained within the envelope capsid from a helper retrovirus.


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The pseudotype assay was used to profile neutralizing antibody responses against SARS-CoV S in sequential serum samples taken from 41 confirmed SARS patients during the 2003 outbreak in Hong Kong and shows long-lasting immunity in most recovered patients.
As a graduate student at the time, I observed that CEF of COFAL-positive embryos complemented envelope-defective Rous sarcoma virus, yielding pseudotype viruses with xenotropic properties.
 
 
 
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