Sometimes photosensitizing drugs may also cause pseudoporphyria (skin lesions similar to porphyria cutanea tarda), e.
Pathogenesis, characteristics, diagnosis and treatment of pseudoporphyria.
In the case of pseudoporphyria
, the most likely culprit is naproxen.
The differential diagnosis includes phototoxic and photoallergic skin reactions, porphyrias and pseudoporphyria
, lupus erythematosus, and polymorphous light eruption.
also presents with skin blistering, but porphyrins are normal.
Solar rashes such as urticaria, actinic prurigo, polymorphic light eruptions, chronic dermatitis, and pseudoporphyria
A case of haemodialysisassociated pseudoporphyria
successfully treated with oral N-acetylcysteine.
When considering a diagnosis of EP, you'll need to rule out erythropoietic protoporphyria, porphyria cutanea tarda, variegate porphyria, xeroderma pigmentosum, and pseudoporphyria
Cutaneous Reaction Patterns to Drugs Clinical Pattern Selected Drug Examples Acneiform lithium, corticosteroids, androgens Lichenoid thiazides, antimalarials, captopril Fixed drug eruption tetracyclines, sulfonamides, barbiturates Morbilliform beta-lactam antibiotics, calcium channel blockers Urticarial beta-lactam antibiotics, aspirin Pityriasis rosea-like captopril, gold Pigmentation minocycline, antimalarials, bleomycin Subacute lupus-like hydrochlorothiazide, terbinafine Systemic lupus-like procainamide, hydralazine, minocycline Serum sickness-like cefaclor, minocycline Pemphigus-like captopril, penicillamine Pseudoporphyria
naproxen, furosemide Photosensitivity doxycycline, thiazides, sulfonylureas Source: Dr.
This type of atrophia maculosa varioliformis cutis, which is more frequently referred to as anetoderma or drug-induced pseudoporphyria
, can occur in patients taking other NSAIDs but the incidence appears to be highest in those taking naproxen.
Our method provides a specific diagnosis of PCTRF and clearly differentiates it from pseudoporphyria
of renal failure.
No new adverse experiences were identified other than a single case of pseudoporphyria
(a photo-induced blistering reaction), an adverse event that has been seen in patients with JRA treated with non-selective NSAIDs.