pseudohypoparathyroidism

pseudohypoparathyroidism /pseu·do·hy·po·para·thy·roi·dism/ (-hi?po-par?ah-thi´roi-dizm) a hereditary condition resembling hypoparathyroidism, but caused by failure of response to parathyroid hormone, marked by hypocalcemia and hyperphosphatemia.

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pseu·do·hy·po·par·a·thy·roid·ism (sd-hp-pr-throi-dzm)

n.

A sex-linked disorder resembling hypoparathyroidism, but which is unresponsive to treatment with parathyroid hormone; it is characterized by short stature, round face, achondroplasia, calcification of basal ganglia, true ectopic bone in fascial planes and skin, mental deficiency, hypocalcemia, hyperphosphatemia, and parathyroid tissue that is hyperplastic. Also called Seabright bantam syndrome.

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pseudohypoparathyroidism

a condition in which there are changes characteristic of hypoparathyroidism (hypocalcemia and hyperphosphatemia) in association with hyperactive parathyroid glands and increased blood levels of parathyroid hormone. It is the result of nonresponsive target cells in bone and kidneys. Not reported in animals.

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pseudohypoparathyroidism Endocrinology A hypoparathyroid-like state–hypocalcemia, hyperphosphatemia due to end-organ resistance to PTH by bone and kidney, with a loss of renal tubule response to PTH, accompanied by ↑ PTH secretion and parathyroid gland–PG hyperplasia; despite excess PTH secretion in response to hypocalcemia by a normal or hyperplastic PG, the condition is associated with a 2º hypocalcemia-induced ↑ in parathyroid function–administration of pharmacologic doses of PTH normally results in ↑ urinary phosphate excretion and ↑ cAMP, but not in pseudohypoparathyroidism; the pattern of heredity is unclear, ♂:♀ ratio is 2:1; changes include a round face, dental dysplasia, dry coarse hair, mental retardation