pseudohyponatremia

pseudohyponatremia

 [soo″do-hi″po-nah-tre´me-ah]
a decreased serum sodium concentration that does not correspond to a real hypotonic disorder, i.e., the serum osmolality is normal. It occurs when hyperlipemia increases the serum non-water volume or hyperproteinemia increases the serum non-sodium solute.

pseu·do·hy·po·na·tre·mi·a

(sū'dō-hī'pō-nă-trē'mē-ă),
A low serum sodium concentration due to volume displacement by massive hyperlipidemia or hyperproteinemia; also used to describe the low serum sodium concentration that may occur with high blood glucose.

pseudohyponatremia

[-hī′pōnātrē′mē·ə]
a decreased sodium concentration that does not correspond to a true hypotonic disorder. It may result instead from volume displacement by massive hyperlipidemia or hyperproteinemia.

pseudohyponatremia

Spuriously low sodium levels due to either
1. Intrinsic properties of a Pt sample–eg, hyperglycemia or hyperproteinemia–displacement of plasma water or due to the cationic nature of monoclonal proteins which bind sodium, hyperlipidemia or hyperviscosity or.
2. Analytic factors, which occur when preparing samples for flame photometry or indirect potentiometry Management Both respond to vitamin 1,25–OH2D3.

pseu·do·hy·po·na·tre·mi·a

(sū'dō-hī'pō-nă-trē'mē-ă)
A low serum sodium concentration due to volume displacement by massive hyperlipidemia or hyperproteinemia; also used to describe the low serum sodium concentration that may occur with high blood glucose.
Synonym(s): pseudohyponatraemia.

pseudohyponatremia

a condition in which marked increases in serum proteins or lipids decrease the percentage of serum water and therefore sodium.
References in periodicals archive ?
The low sodium concentration was found to be a result of pseudohyponatremia, an artificially low measurement of sodium concentration produced by the presence of severe hyperproteinemia.
In this case, the volume displacement effect was suspected as the most likely etiology of the pseudohyponatremia.
of measurement is termed pseudohyponatremia in the context of physiologically normal sodium levels and pseudonormonatremia when the result masks physiologically increased sodium.
3,4) Displacement of water in a sample may lead to pseudohyponatremia when electrolytes are measured by indirect methods.
IVIG THERAPY RESULTS IN POSTINFUSIONAL HYPERVISCOSITY AND PSEUDOHYPONATREMIA ATTRIBUTABLE TO HYPERPROTEINEMIA.
Pseudohyponatremia may be circumvented by measuring sodium with a direct ion-selective electrode or by measuring serum osmolality (low in hyponatremia and normal in pseudohyponatremia).
First, analytical error should always be considered, including the possibility that the hyponatremia is in fact pseudohyponatremia.
When sodium is measured by indirect methods, pseudohyponatremia due to a high serum protein or lipid content does not usually lower the sodium concentration to the degree observed in this case; however, the multiple potential sources of large errors in sodium measurements should be considered (e.
In addition to the effects on Lp analyses described here, high LpX may result in pseudohyponatremia (9) and falsely increased laboratory measurement of Lp(a) (10).
For this reason, we set the maximum tolerable deviation attributable to interference in assays for sodium and chloride at 5% to avoid wrong interpretation resulting from pseudohyponatremia or pseudohypochloremia (11).
Anticonvulsant therapy Cerebral edema Exclude pseudohyponatremia ?
Pseudohyponatremia is said to be less likely encountered with ion-selective electrode methods, without distinction made between diluted and nondiluted ISE methodology.
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