pseudohyperaldosteronism


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pseudohyperaldosteronism

Liddle syndrome An AD aldosteronism-like condition characterized by severe HTN and spontaneous hypokalemia
(K+ wasting) leading to hypokalemic alkalosis with ↓ aldosterone secretion Treatment KCl, amiloride and triamterene to prevent K+ wasting, sodium restriction; renal transplantation. Cf Hyperaldosteronism.
References in periodicals archive ?
Pseudohyperaldosteronism presents with low aldosterone and low renin and may result from genetic or acquired etiologies.
8) Fluoroprednisolone and 9[alpha]-fluorocortisol have considerable direct mineralocorticoid activity; in large amounts they produce arterial hypertension with a clinical picture of pseudohyperaldosteronism (increased exchangeable sodium and blood volume, hypokalemic metabolic alkalosis, and suppressed plasma renin and aldosterone levels).
However, there exists a sensitive subset of the population who appears to show signs of pseudohyperaldosteronism at lower exposures than those which produce effects in the general population.

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