pseudogene


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Related to pseudogene: Synonymous substitution, Genome duplication

pseu·do·gene

(sū'dō-jēn),
1. A sequence of nucleotides that is not transcribed and therefore has no phenotypic effect.
2. An inactive DNA segment that arose by a mutation of a parental active gene.

pseudogene

(so͞o′də-jēn′)
n.
A segment of DNA that resembles a gene but is not functional and usually not transcribed. Pseudogenes often have functional paralogs in the same organism.

pseudogene

[so̅o̅′dōjēn′]
Etymology: Gk, pseudes + genein, to produce
a DNA sequence that resembles a gene and may be derived from one but lacks a genetic function.

pseudogene

a nucleotide sequence, similar to that of a known functional gene, but that is inactive due to the accumulation of MUTATIONS. A pseudogene may result from a tandem DUPLICATION of an existing gene or REVERSE TRANSCRIPTION of the transcript of the gene (so that it lacks the introns and has a POLY(A) TAIL).

pseudogene

a nonfunctional DNA sequence, nearly homologous to a functional gene.
References in periodicals archive ?
vivax Sal-I genome, has revealed a total of 346 vir genes including fragments, and pseudogenes (5, 22).
But now, a new study led by scientists at The Scripps Research Institute (TSRI) shows how pseudogenes can regulate the activity of a cancer-related gene called PTEN.
Evolutionists have argued that the existence of the nonfunctional GULO pseudogene in primates in the context of functional GULO among other mammals is strong evidence for common ancestry.
Whiley DM, Limnios A, Moon NJ, Gehrig N, Goire N, Hogan T, et al: False-negative results, using Neisseria gonorrhoeae porA pseudogene PCR- a clinical gonococcal isolate with an N.
Argininosuccinate lyase deficiency: mutational spectrum in Italian patients and identification of a novel ASL pseudogene.
This large gene, of approximately 178 kilobases, is situated on chromosome 12 (with a pseudogene located on chromosome 22).
gertschi sequence represents the functional 18S rRNA gene rather than a pseudogene copy or experimental artifact.
It also addresses an additional issue unique to PMS2--the PMS2CL (PMS2 C-terminal like pseudogene) pseudogene (66).
In Sd197 and Ss046 (late lactose-fermenting strains), the key gene, lacZ (encoding b-D-galactosidase) is intact, although lacY (encoding galactose permease) is a pseudogene (12).
In the method, the internal control of amplification is present which rules out any PCR artifact when rearrangement of NEMO or pseudogene is absent, but this test cannot discriminate between NEMO and psudogene rearrangement.