Microscopic description Reese and Colclasure, 1975 (5) Pseudoepitheliomatous hyperplasia
and granulomatous inflammation Smallman et al, 1989 (4) Pseudoepitheliomators hyperplasia and granulomatous inflammation Browning et al, 1992 (7) Granulomatous inflammation Isaacson and Frable, 1996 (6) Pseudoepitheliomatous hyperplasia
and granulomatous inflammation McGregor et al, 2003 Pseudoepitheliomatous hyperplasia
, granulomatous inflammation, and mild acute inflammation Series (ref.
The histologic findings after review were ulceration and granulation tissue formation, granuloma, multinucleated giant cells with many intracytoplasmic LeishmanDonovan bodies, numerous multinucleated giant cells, severe lymphoplasma cells, infiltrating perineural tissue and muscles, pseudoepitheliomatous hyperplasia
with keratin pearls, lymphoid aggregation in the submucosal area, lymphoid aggregation between skeletal muscles, and massive infiltration of macrophages loaded with Leishman-Donovan bodies in submucosal areas of oral (Figure 3), nasal, and respiratory epithelium.
The overlying nonkeratinizing squamous epithelium was unremarkable and lacked pseudoepitheliomatous hyperplasia
Immediately overlying the mass, the epithelium demonstrates pseudoepitheliomatous hyperplasia
in most cases (figure 1).
This process, termed pseudoepitheliomatous hyperplasia
(PEH; or pseudocarcinomatous hyperplasia), is potentially associated with organoid nevi, nonhealing ulcers, chronic dermatitides, reactions to underlying neoplasms, and selected infections of the skin.
of the overlying squamous mucosa is commonly present when the lesion involves the palate.
In an attempt at re-epithelialization, necrotizing sialometaplasia may induce pseudoepitheliomatous hyperplasia
, and this reaction may be so strilting that distinguishing it from squamous cell carcinoma and mucoepidermoid carcinoma may be difficult.
To our knowledge, this is the first case to be reported with such an association and may raise new questions about the significance of pseudoepitheliomatous hyperplasia
commonly seen with GCTs at various body sites.
2,18] In our patient, the histopathologic findings were associated with these characteristics in both the subcutaneous cervical tumor and the laryngeal tumor, but pseudoepitheliomatous hyperplasia
was not observed.
Correlation with clinical findings and history is essential to avoid misdiagnosing HLE as squamous neoplasia or other lichenoid interface dermatitides with pseudoepitheliomatous hyperplasia
The immediately adjacent epithelium will frequently show pseudoepitheliomatous hyperplasia
, while the ulcer bed contains granulation tissue (figure 2).
Biopsy showed pseudoepitheliomatous hyperplasia
, granulomata, and small, short budding yeast forms.