pseudocholinesterase deficiency


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pseu·do·cho·lin·es·ter·ase de·fi·cien·cy

[MIM*177400]
an autosomal dominant disorder manifested by exaggerated responses to drugs ordinarily hydrolyzed by serum pseudocholinesterase (for example, succinylcholine); believed to entail production of a variant enzyme that is less active than the normal enzyme in hydrolyzing appropriate substrates, but also abnormally resistant to the effects of anticholinesterases, caused by mutation in the pseudocholinesterase E1 gene (CHE1) on 3q.

pseu·do·cho·lin·es·ter·ase de·fi·cien·cy

(sūdō-kōlin-estĕr-ās dĕ-fishĕn-sē) [MIM*177400]
Disorder with exaggerated responses to drugs ordinarily hydrolyzed by serum pseudocholinesterase.
References in periodicals archive ?
In addition to its application as a nerve agent medical countermeasure, rBChE may also have utility addressing pesticide overdose or certain orphan drug indications such as pseudocholinesterase deficiency, which is a condition that results in increased sensitivity to certain muscle relaxant drugs used during general anesthesia.
Rocuronium antagonized by sugammadex for series of electroconvulsive therapy in a patient with pseudocholinesterase deficiency.
A 17-year-old girl with a history of von Willebrand' s disease and pseudocholinesterase deficiency was referred to our department with a 1-year history of a progressively enlarging tongue mass.
Patients with severe hepatic disease or pseudocholinesterase deficiency are at greater risk of developing toxic plasma concentrations.
Batistaki et al recently reported a patient with another contraindication to succinylcholine, pseudocholinesterase deficiency, where rocuronium (0.