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pseudocholinesterase

   Also found in: Acronyms, Wikipedia 0.02 sec.
pseudocholinesterase /pseu·do·cho·lin·es·ter·ase/ (PCE) (soo″do-ko″lin-es´ter-ās) cholinesterase.
pseudocholinesterase.
pseudocholinesterase

pseudocholinesterase
A liver and plasma enzyme that rapidly metabolizes succinylcholine, a short-acting–5-10 mins–neuromuscular anesthetic, thereby controlling its duration of action; some people have congenital PChe variants, in which neuromuscular block is prolonged with usual doses of succinylcholine–and identified by determining the 'dibucaine' number; PChe activity may be ↓ in various acquired conditions–eg, liver disease–hepatitis, cirrhosis, metastasis, malnutrition, acute infections, anemia, MIs, CA, pregnancy, cytotoxic drugs, acetylcholinesterase inhibitors, dermatomyositis. See Dibucaine number.


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