pseudocholinesterase


Also found in: Dictionary, Acronyms.
Related to pseudocholinesterase: atypical pseudocholinesterase

bu·tyr·o·cho·lin·es·ter·ase

(byū'tir-ō-kō'lin-es'ter-ās),
Pseudocholinesterase or plasma cholinesterase.
See also: cholinesterase.

pseudocholinesterase

/pseu·do·cho·lin·es·ter·ase/ (PCE) (soo″do-ko″lin-es´ter-ās) cholinesterase.

pseudocholinesterase

BCHE

A gene on chromosome 3q26.1-2 that encodes butyrylcholinesterase, which has a broad substrate spectrum. It contributes to inactivation of the neurotransmitter acetylcholine and can degrade neurotoxic organophosphate esters.
 
Molecular pathology
Mutant alleles at BCHE are responsible for suxamethonium sensitivity.

pseudocholinesterase

A liver and plasma enzyme that rapidly metabolizes succinylcholine, a short-acting–5-10 mins–neuromuscular anesthetic, thereby controlling its duration of action; some people have congenital PChe variants, in which neuromuscular block is prolonged with usual doses of succinylcholine–and identified by determining the 'dibucaine' number; PChe activity may be ↓ in various acquired conditions–eg, liver disease–hepatitis, cirrhosis, metastasis, malnutrition, acute infections, anemia, MIs, CA, pregnancy, cytotoxic drugs, acetylcholinesterase inhibitors, dermatomyositis. See Dibucaine number.

plas·ma chol·ine·ste·rase

(plaz'mă kō'lin-es'tĕr-ās)
A type of cholinesterase found in plasma.
See also: fluoride number
Synonym(s): butyrylcholinesterase, pseudocholinesterase.

pseudocholinesterase

References in periodicals archive ?
In most patients, Succinylcholine is rapidly degraded by pseudocholinesterase leading to a short duration of action (9-13 minutes).
The familial incidence of low pseudocholinesterase level.
Follow-up pseudocholinesterase levels on day 3 after admission had improved to 2.
BuChE, also called pseudocholinesterase or plasma cholinesterase, is an enzyme genetically different from ACHE, although they share some important functions, such as ACh hydrolysis (Darvesh et al.
Most patients can convert succinylcholine into inert metabolites through an enzyme called pseudocholinesterase because most patients possess two alleles for the common gene that can produce active enzyme.
6 g/dL, pseudocholinesterase 2,099 U/L, HIV-DNA virus count 500 copies/mL, CD4+ lymphocyte count 29 x [10.
A 17-year-old girl with a history of von Willebrand' s disease and pseudocholinesterase deficiency was referred to our department with a 1-year history of a progressively enlarging tongue mass.
instructions for making the pseudocholinesterase enzyme,[sup][14] which has a variety of physiological effects such as the metabolism of the cocaine and heroin [sup][15] and the breakdown of organophosphorus esters.
ASA Grade > II patients, Age <15 years and >60 years, Pregnant and lactating women, Patients with family history S/o altered pseudocholinesterase function, Patients with NM disorders, muscular dystrophies, head injuries, renal disorders, hepatic disorders and dyselectrolytemia, CVS disorders, Diabetes mellitus, diuretics and on the drugs which interfere with neuromuscular function, anticipated difficult airway, Morbidly obese patients (BMI>30), Patients with history of burns (Within past 1 year), Patients at increased risk of gastric aspiration.
Rocuronium antagonized by sugammadex for series of electroconvulsive therapy in a patient with pseudocholinesterase deficiency.