pseudocholinesterase


Also found in: Dictionary, Acronyms.
Related to pseudocholinesterase: atypical pseudocholinesterase

bu·tyr·o·cho·lin·es·ter·ase

(byū'tir-ō-kō'lin-es'ter-ās),
Pseudocholinesterase or plasma cholinesterase.
See also: cholinesterase.

pseudocholinesterase

/pseu·do·cho·lin·es·ter·ase/ (PCE) (soo″do-ko″lin-es´ter-ās) cholinesterase.

pseudocholinesterase

BCHE

A gene on chromosome 3q26.1-2 that encodes butyrylcholinesterase, which has a broad substrate spectrum. It contributes to inactivation of the neurotransmitter acetylcholine and can degrade neurotoxic organophosphate esters.
 
Molecular pathology
Mutant alleles at BCHE are responsible for suxamethonium sensitivity.

pseudocholinesterase

A liver and plasma enzyme that rapidly metabolizes succinylcholine, a short-acting–5-10 mins–neuromuscular anesthetic, thereby controlling its duration of action; some people have congenital PChe variants, in which neuromuscular block is prolonged with usual doses of succinylcholine–and identified by determining the 'dibucaine' number; PChe activity may be ↓ in various acquired conditions–eg, liver disease–hepatitis, cirrhosis, metastasis, malnutrition, acute infections, anemia, MIs, CA, pregnancy, cytotoxic drugs, acetylcholinesterase inhibitors, dermatomyositis. See Dibucaine number.

plas·ma chol·ine·ste·rase

(plaz'mă kō'lin-es'tĕr-ās)
A type of cholinesterase found in plasma.
See also: fluoride number
Synonym(s): butyrylcholinesterase, pseudocholinesterase.

pseudocholinesterase

References in periodicals archive ?
Is pseudocholinesterase activity related to markers of triacylglycerol synthesis in type II diabetes mellitus?
Mutual influence of cholesterol esterase and pseudocholinesterase on the biodegradation of dental composites.
Data regarding pseudocholinesterase activity in unseparated blood after storage at room temperature are rare, however, with the longest reported duration (48 h) showing only negligible differences (2).
Kalow discovered that a genetically based deficiency in the metabolizing enzyme pseudocholinesterase was responsible, and proceeded to describe the population incidence of the various alleles responsible for the deficiency.
com 3,4,5,9 PSEUDO-HURLER POLYDYSTROPHY See: Mucopolysaccharidosis; Tay-Sachs Disease PSEUDOCHOLINESTERASE DEFICIENCY See: Malignant Hyperthermia PSEUDOXANTHOMA ELASTICUM (PXE) See also: Connective Tissue Disorders; Heart Disorders; Macular Diseases; Visual Impairments National Association for Pseudoxanthoma Elasticum 3500 E.
A kinetic method for determination of the activity of pseudocholinesterase (acylcholine acyl-hydrolase 3.
690 Los Angeles, CA 90095 (310) 825-6865 (310) 794-9962 (fax) 3,4,9 PSEUDO-HURLER POLYDYSTROPHY See: Mucopolysaccharidosis; Tay-Sachs Disease PSEUDOCHOLINESTERASE DEFICIENCY See: Malignant Hyperthermia PSEUDOXANTHOMA ELASTICUM (PXE) See also: Connective Tissue Disorders; Heart Disorders; Macular Diseases; Visual Impairments National Association for Pseudoxanthoma Elasticum 3500 E.
Patients exposed to substances that produce cholinergic response can be screened for the presence of low pseudocholinesterase activity (101).
Albumin, pseudocholinesterase (PCHE), alkaline phosphatase, [gamma]-glutamyltransferase, cholesterol, LDL- and HDL-cholesterol, triglycerides, total and direct bilirubin, and aspartate and alanine aminotransferase (AST and ALT) were measured using standard methodologies (Boehringer).
18) have reported an automated method for the determination of both acetyl- and pseudocholinesterase activity in hemolyzed whole blood.
Seven of the more frequently investigated analytes were selected for the study on the basis of the criteria representativeness for different groups of tests, frequency of tests, and bearable costs: sodium, potassium, calcium, creatinine, [gamma]-glutamyltransferase, alkaline phosphatase, and pseudocholinesterase.