As gynecologists, we worry about psammoma bodies
, because they are frequently associated with ovarian serous papillary carcinomas as well as other .
The risk of malignancy is actually very low when you have psammoma bodies
present on a Pap smear, assuming the patient is asymptomatic, she has an unremarkable physical examination, and the background cytology is normal," Dr.
Microscopic changes observed included focal loss of Purkinje cells, occasional microglial clustering, and psammoma bodies
Another group (22) also found that the cytologic findings for the primary cutaneous meningioma were similar to findings characteristic of central nervous system meningioma, with bland nuclei, cellular whorls, and psammoma bodies
Papillae 5 (19) Pseudo-papillae 9 (35) Psammoma bodies
5 (19) Nuclear grooves 11 (42) Nuclear overlap 13 (50) "Orphan Annie" nuclei 6 (23) Nuclear pseudo-inclusions 9 (35) Nucleoli 9 (35) Hypercellularity 21 (81) Colloid scalloping 17 (65) Eosinophilic cytoplasm 10 (38) Cytologic atypia 18 (69) Nuclear pleomorphism 15 (58) Vascular invasion 1 (4) Mitoses ([greater than or 11 (42) equal to]1 mitosis per 10 HPF) Patients With Biologically Feature Malignant Disease (n = 26), No.
Although mitotic figures are infrequent and nucleoli are inconspicuous, psammoma bodies
may be present.
3) These tumors often show collections of foamy macrophages within the papillary stalks, iron deposition, and psammoma bodies
The identification of psammoma bodies
in the context of a thyroid-type papillary neoplasm is highly supportive in the diagnosis of malignancy.
Pathologic study of the specimen confirmed a diagnosis of transitional meningioma with psammoma bodies
Nuclear atypia, stratification, mitoses, necrosis, psammoma bodies
, and invasion of surrounding structures are absent.
These tumors often have a pure glandular growth pattern with scattered psammoma bodies
and may be confused with conventional adenocarcinomas.
2 translocation RCC is a carcinoma with mixed papillary and nested/alveolar architecture, composed of cells with clear and/or eosinophilic, granular, voluminous cytoplasm; discrete borders; vesicular chromatin; prominent nucleoli; and the presence of extensive psammoma bodies
(Figures 1 through 4).