The accumulation of substances not adequately removed by dialysis that can induce pruritus, called pruritogenic substances, has been implicated as another potential mechanism.
However, it does not seem to be pruritogenic itself, as it does not induce pruritus when injected into the skin (Manenti, Tansinda, & Vaglio, 2009).
Chronic pruritus, secondary to abnormal bile flow and retention of pruritogenic
chemicals, including bile acids, usually heralds decompensation of the liver disease.
Traditional treatment with antihistamines is only useful for the sedative effect, however recent advances in understanding the neurophysiology of itch have led to new therapies targeted at different pruritogenic
mechanisms including opioid antagonists (e.
The underlying pruritogenic
stimuli in many LSC cases often remain undetermined.
To precisely measure itch in animal behavioral experiments, we should focus on itch-related behaviors that are elicited only by pruritogenic stimuli but not by other sensory stimuli like pain.
Fjellner B, Hagermark O (1981) Studies on pruritogenic and histamine-releasing effects of some putative peptide neurotransmitters, Acta Derm Venereol 61:245-250