prozone

(redirected from prozone reaction)

prozone

 [pro´zōn]
in an agglutination or precipitation reaction, the zone of relatively high antibody concentrations within which no reaction occurs. As the antibody concentration is lowered below the prozone, the reaction occurs. This phenomenon may be due simply to antibody excess or it may be due to blocking antibody or to nonspecific inhibitors in serum.

pro·zone

(prō'zōn),
In the case of agglutination and of precipitation, the phenomenon in which visible reaction does not occur in mixtures of specific antigen and antibody because of antibody excess.
Synonym(s): prezone

prozone

/pro·zone/ (pro´zōn) the phenomenon exhibited by some sera, in which agglutination or precipitation occurs at higher dilution ranges, but is not visible at lower dilutions or when undiluted.

pro·zone

(prō'zōn)
A phenomenon in which visible agglutination and precipitation do not occur in mixtures of specific antigen and antibody because of antibody excess.

prozone

the phenomenon exhibited by some sera, in which agglutination or precipitation occurs at higher dilution ranges, but is not visible at lower dilutions or when undiluted.
Mentioned in ?
References in periodicals archive ?
The prozone reaction occurs when the clinical sample contains antibody molecules in excess of the number of antigen binding sites available.
The limitations include increased rate of negative serology test in both primary and secondary syphilis, increase false-negative non- treponemal antibody test due to prozone reaction, high rate of serological failure to clear non-trepone- mal antibody test after treatment and seroreversion to negative of specific treponemal antibody tests following treatment.