proximal tubule


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Related to proximal tubule: loop of Henle, Distal tubule

proximal tubule

The first part of the tubular system of a nephron after the Bowman's capsule. It has convoluted and straight segments and is followed by the distal tubule.

proximal tubule

the convoluted tube between the loop of Henle and Bowman's capsule in the vertebrate kidney.

tubule

a small tube; a minute canal found in various structures or organs of the body.

collecting t's
the terminal channels of the nephrons which open on the summits of the renal papillae or renal crests.
convoluted t's
channels which follow a tortuous course. See also renal tubules (below) and tubuli contorti.
dentinal t's
minute channels in the dentine of a tooth that extend from the pulp cavity to the cement or the enamel. Called also dentinal canaliculi.
galactophorous t's
small channels for the passage of milk from the secreting cells in the mammary gland. Called also lactiferous ducts.
Henle's t's
see henle's tubules.
lactiferous t's
see lactiferous ducts.
mesonephric t's
the tubules comprising the mesonephros, or temporary kidney, of amniotes.
metanephric t's
the tubules comprising the permanent kidney of amniotes.
proximal tubule
intrarenal site for the reabsorption of most of the protein in the tubular fluid.
proximal convoluted tubule
the portion of the nephron immediately succeeding the glomerulus; susceptible to disease because of its early exposure to toxins in the glomerular filtrate.
renal t's
the minute canals made up of basement membrane and lined with epithelium, composing the substance of the kidney and secreting, reabsorbing, collecting and conducting the urine. Include proximal convoluted, the nephron loop (containing the proximal straight tubule, descending and ascending thin, and the distal straight tubules) and the distal convoluted tubules.
seminiferous t's
the tubules of the testis, in which spermatozoa develop and through which they leave the gland.
uriniferous t's
renal tubules; channels for the passage of urine.
References in periodicals archive ?
In the current study, demonstration of increased plasma MIOX following AKI may also be related to necrosis of the proximal tubule, although secretion cannot be ruled out.
The renal cortical tissue was used for proximal tubule isolation or mitochondria isolation.
16) Invariably, if we saw such stenotic connections, the proximal tubules, belonging to glomeruli with periglomerular fibrosis, were atrophic with thickened tubular basement membranes and simplified epithelium, lacking brush borders.
These findings suggested that injected cadmium initially is segregated in a nontoxic complexed form as metallothionein in the cytoplasm of the proximal tubule, but when the organism's capacity to synthesize new metallothionein is exhausted, the cadmium, now less firmly bound to high molecular weight proteins, moves to other cell organelles, where the ATP-Na-K-ATPase transport system is affected (42-44).
An extensive endocytic apparatus, located in the apical membrane of proximal tubule cells, plays a key role in the reabsorption and degradation of glomerular-filtered albumin and low-molecular-weight proteins (Marshansky et al.
MDCK cells have been widely used as a model system for the distal/collecting duct and LLC-PK1 cells have retained many characteristics of the proximal tubule (Gstraunthaler et al.
Friberg and associates (23) concluded that the critical effect following chronic exposure of humans to Cd was proteinuria resulting from damage to the proximal tubule cells of the kidney.
Lithium is freely filtered through the glomerulus and reabsorbed by the proximal tubule in the same proportion as sodium (60%-65%); another 15% to 20% is reabsorbed beyond the proximal tubule, and 20% is excreted in the urine.
9:00 CADMIUM INDUCED ALTERATION OF CADHERIN EXPRESSION IN THE MT-3 TRANSFECTED HUMAN PROXIMAL TUBULE CELL LINE HK-2, Chandra S Bathula; Scott H.
The proximal tubule removes substantial but ill-defined amounts of peptides and proteins from the filtrate.
Data were also presented that showed CMX157 is not a substrate in vitro for human Organic Anion Transporter 1 (hOAT1), which actively transports tenofovir into renal proximal tubule cells of the kidney and is linked to tenofovir-induced nephrotoxicity.
Materials and methods: The effects of three commercially available Devil's Claw preparations and that of pure harpagoside were studied in the human kidney (HK-2) proximal tubule cell line, constitutively expressing ABCBl/P-glycoprotein (P-gp).