provirus


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provirus

 [pro-vi´rus]
a DNA transcript of an RNA virus that migrates from the cytoplasm into the nucleus and integrates into the host genome by crossing over so that it will be thus replicated in the daughter cells.

pro·vi·rus

(prō-vī'rŭs),
The precursor of an animal virus, usually a retrovirus; theoretically analogous to the prophage in bacteria, the provirus is integrated in the nucleus of infected cells and can be activated in response to certain stimuli.

provirus

/pro·vi·rus/ (pro-vi´rus) the genome of an animal virus integrated (by crossing over) into the chromosome of the host cell, and thus replicated in all of its daughter cells. It can be activated to produce a complete virus; it can also cause transformation of the host cell.

provirus

(prō′vī′rəs, prō-vī′-)
n. pl. provi·ruses
A form of a virus that allows it to be integrated into the genome of a host cell and to replicate in concert with the cell's genetic material without causing cell lysis.

pro′vi′ral (-rəl) adj.

provirus

[-vī′rəs]
a stage of viral replication in which the viral genetic information has been integrated into the genome of the host cell. It may be activated spontaneously or by a specific stimulus to direct the cell to produce new virions to progress to a complete virus.

pro·vi·rus

(prō-vī'rŭs)
The precursor of an animal virus; theoretically analogous to the prophage in bacteria, the provirus being integrated into the nucleus of infected cells.

provirus

the DNA of a VIRUS that has integrated into the DNA of the host CELL and is transmitted from one cell generation to the next in this state. No infective virus particles are produced. The provirus can excise from the host's DNA and resume a productive viral cycle with the production of virus particles.

pro·vi·rus

(prō-vī'rŭs)
The precursor of an animal virus; theoretically analogous to the prophage in bacteria, the provirus being integrated into the nucleus of infected cells.

provirus (prōvī´rus),

n a type of virus incorporated into a host cell's genetic material that transmits from one generation of cells to the next via cell replication without triggering the separation or decomposition of the cell.

provirus

the genome of an animal virus integrated into the chromosome of the host cell, and thus transferred to in all of its daughter cells.
References in periodicals archive ?
Then, after testing to make sure no virus or provirus can be found, we would then stop using the powerful drugs and see if the virus comes back.
The presence of ancient human T-cell lymphotropic virus type I provirus DNA in an Andean mummy.
The HTLV-I provirus genome is 9032 bp long and contains the gag, pol, and env genes, which encode the viral matrix; capsid and nucleocapsid proteins; enzymes such as reverse transcriptase, integrase, and protease; and envelope protein consisting of a surface glycoprotein and a transmembrane protein.
The diversity of populations of provirus may predict the diversity of genital secretion populations since provirus represents the earliest archived virus.
If some of the viral RNA is replaced with RNA coding for a useful protein, integration of the provirus may provide missing genetic instructions for making the protein in a patient with a genetic disease.
Human T-lymphotropic virus type 2 (HTLV-2) provirus in circulating cells of the monocyte/macrophage lineage in patients dually infected with human immunodeficiency virus type 1 and HTLV-2 and having predominantly sensory polyneuropathy.
No infectious EAVs have yet been isolated, nor has a full-length intact EAV provirus been identified (25).
Provirus load changes in untreated and zidovudine-treated human immu- nodeficiency virus type 1-infected patients.
AIDFAREL(TM) inhibits both the replication and transcription of the integrated viral DNA known as a provirus by using the drug technology termed Binary Molecular DNA Clamp (BMC).
They act by blocking the action of the integrase, a viral enzyme that inserts the viral genome into the DNA of the host cell preventing so the formation of the provirus.
At present, one of our major challenges lies in materializing our ambitions in the field of genetic and viral diseases; with the ACTIVE research program, we are focusing on a novel approach, which seeks to destroy the HIV provirus with meganucleases and brings new hope to treat these chronic infections.
Verdin's group has demonstrated that SirT1 deacetylates the HIV TAT protein, a component of the viral transcription machinery that is required for transcription of the HIV provirus, and could therefore play a critical role in the progression of HIV infection.