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prourokinase

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prourokinase /pro·uro·ki·nase/ (pro-UK) (pro″u-ro-ki´nās) the single chain proenzyme cleaved by plasmin to form u-plasminogen activator (urokinase); it is slowly activated in the presence of fibrin clots and is used for therapeutic thrombolysis.


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This work is supported by the results reported in the Prolyse in Acute Cerebral Thromboembolism trial, (10) which showed a significant benefit for intra-arterial therapy with prourokinase within a 6-hour window from the onset of symptoms.
The FSAP Marburg I variant has a reduced ability to activate prourokinase, but has retained its potential to activate factor VII.
 
 
 
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