protoporphyrin


Also found in: Dictionary, Wikipedia.
Related to protoporphyrin: Zinc Protoporphyrin

protoporphyrin

 [pro″to-por´fĭ-rin]
a porphyrin whose iron complex united with protein occurs in hemoglobin, myoglobin, and certain respiratory pigments. It is accumulated and excreted excessively in the feces in erythropoietic protoporphyria and variegate porphyria.

protoporphyrin

/pro·to·por·phy·rin/ (-por´fĭ-rin) any of several porphyrin isomers, one of which is an intermediate in heme biosynthesis; it is accumulated and excreted excessively in feces in erythropoietic protoporphyria and variegate porphyria.

protoporphyrin

(prō′tō-pôr′fə-rĭn)
n.
A metal-free porphyrin, C34H34N4O4, that combines with ferrous iron to form the heme group in hemoglobin and myoglobin, and with ferric iron to form the hemin group in catalase and some cytochromes.

protoporphyrin

[prō′tōpôr′firin]
Etymology: Gk, protos + porphyros
a kind of porphyrin that combines with iron and protein to form various important organic molecules, including catalase, hemoglobin, and myoglobin. See also heme.

protoporphyrin

A porphyrin occurring in the course of the synthesis of HAEMOGLOBIN. Excess of this porphyrin, protoporphyria, causes intense itching, swelling and redness of the skin on exposure to sunlight and leads to a strikingly weatherbeaten appearance.

Protoporphyrin

A precursor molecule to the porphyrin molecule.
Mentioned in: Porphyrias

protoporphyrin

a porphyrin whose iron complex united with protein occurs in hemoglobin, myoglobin and certain respiratory pigments.

protoporphyrin III
combines with 4 moles of iron to form the heme moiety of hemoglobin.
References in periodicals archive ?
In the case of EPP, type of protoporphyrin called protoporphrin IX accumulates in the red blood cells, plasma and sometimes the liver.
The progression of colors seen in bruises, hemorrhages, or hematomas from red to purple-blue, black, green, and yellow is explained by the conversion of Hb to deoxygenated Hb, heme catabolism to iron and protoporphyrin, and production of biliverdin and bilirubin, respectively.
Further researches on the characteristics of chlorophyll metabolism indicated that the precursors of D-aminolevulinic acid (ALA), porphobilinogen (PBG), uroporphyrinogen III (Urogen III), coproporphyrinogen III (Coprogen III), protoporphyrin IX (Proto IX), Mg-protoporphyrin IX (Mg-Proto IX) and protochlorophyllide (Pchlide) in chlorophyll biosynthesis in Burley21 were lower than in Maryland609 at vigorous growing period; the activity of D-aminolevulinate dehydratase (ALAD) in Burley21 was 0.
25,30] The inhibitory effect of lead acetate on conversion of coproporphyrinogen III to protoporphyrin IX results in shortening of erythrocyte life span and a decrease in the production of Hb.
These include biochemical parameters, namely zinc protoporphyrin and soluble transferrin receptor, as well as haematological parameters, namely the percentage of hypochromic red blood cells, and reticulocyte parameters such as the reticulocyte haemoglobin content (CHr).
67 microg/dL versus normal value: < 40 microg/dL) of erythrocyte zinc protoporphyrin (ZnPP) only.
Iron deficiency is specifically estimated by serum Ferritin, (10) Serum Iron, Total Iron Binding capacity, Red Cell protoporphyrin levels, Bone marrow iron stores and transferrin receptor protein.
This dictionary focuses specifically on current toxicology terminology, from AAALAC (Association for Assessment and Accreditation of Laboratory Animal Care International) to zinc protoporphyrin.
However, when cells are exposed to excess exogenous 5-ALA as a drug, the negative feedback control mechanism of 5-ALA synthesis is bypassed, leading to protoporphyrin IX accumulation in the mitochondria of malignant tissues where ferrochelatase enzyme is absent.
TEHRAN (FNA)- Iranian researchers from Ferdowsi University of Mashhad in association with their colleagues from Mashhad University of Medical Sciences used gold nanoparticles as perfect carrier to deliver the hydrophobic protoporphyrin molecule to cancerous cells.
The active substance in GLIOLAN, aminolevulinic acid (ALA), is a photoreceptive compound which is absorbed by cells in the body, where it is converted by enzymes into fluorescent chemicals, particularly protoporphyrin IX (PPIX).