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protoporphyrin

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protoporphyrin /pro·to·por·phy·rin/ (-por´fĭ-rin) any of several porphyrin isomers, one of which is an intermediate in heme biosynthesis; it is accumulated and excreted excessively in feces in erythropoietic protoporphyria and variegate porphyria.
pro·to·por·phy·rin (prt-pôrf-rn)
n.
A metal-free porphyrin that combines with iron to form the heme of iron-containing proteins.

Protoporphyrin
A precursor molecule to the porphyrin molecule.
Mentioned in: Porphyrias

protoporphyrin
[prō′tōpôr′firin]
Etymology: Gk, protos + porphyros
a kind of porphyrin that combines with iron and protein to form various important organic molecules, including catalase, hemoglobin, and myoglobin. See also heme.

protoporphyrin [pro″to-por´fĭ-rin]
a porphyrin whose iron complex united with protein occurs in hemoglobin, myoglobin, and certain respiratory pigments. It is accumulated and excreted excessively in the feces in erythropoietic protoporphyria and variegate porphyria.

protoporphyrin
a porphyrin whose iron complex united with protein occurs in hemoglobin, myoglobin and certain respiratory pigments.

protoporphyrin III
combines with 4 moles of iron to form the heme moiety of hemoglobin.


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When blood lead is high, an increase in erythrocyte protoporphyrin (EP) follows.
Associations of delta-aminolevulinic acid dehydratase genotype with plant, exposure duration, and blood lead and zinc protoporphyrin levels in Korean lead workers.
A Centers for Disease Control and Prevention (CDC) statement issued in 1991 lowering the blood-lead concentration level deemed harmful to children had the dual effect of 1) rendering the erythrocyte protoporphyrin test unsuitable for lead-screening purposes because of poor specificity and sensitivity, and 2) challenging laboratories to use a direct test for measuring blood-lead concentration that would produce accurate results, both for screening and diagnostic purposes.
 
 
 
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